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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dlk1tm1.2Jvs
targeted mutation 1.2, Jennifer V Schmidt
MGI:5471922
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dlk1tm1.2Jvs/Dlk1tm1.2Jvs involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5471940
ht2
Dlk1tm1.2Jvs/Dlk1+ involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5471941


Genotype
MGI:5471940
hm1
Allelic
Composition
Dlk1tm1.2Jvs/Dlk1tm1.2Jvs
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlk1tm1.2Jvs mutation (0 available); any Dlk1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• authors state that mice exhibit the same defects as in heterozygotes when the allele is inherited paternally

growth/size/body
• authors state that mice exhibit the same defects as in heterozygotes when the allele is inherited paternally

cellular




Genotype
MGI:5471941
ht2
Allelic
Composition
Dlk1tm1.2Jvs/Dlk1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlk1tm1.2Jvs mutation (0 available); any Dlk1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• when the allele is inherited maternally, mice exhibit normal survival
• when the allele is inherited paternally, some mice die within the first few days after birth
• when the allele is inherited paternally, some mice die within the first few days after birth

embryo
• decreased number of glycogen cells with an increase in pre-glycogen cells, when the allele is inherited paternally
• increased in cellularity, when the allele is inherited paternally
• decreased vascularity when the allele is inherited paternally
• reduced size of labyrinth layer when the allele is inherited paternally

growth/size/body
N
• when the allele is inherited paternally, mice exhibit normal embryonic weight
• when the allele is inherited maternally, mice exhibit normal growth
• dwarfism when the allele is inherited paternally
• from 1 to 6 weeks when the allele is inherited paternally
• when the allele is inherited paternally

adipose tissue
• when the allele is inherited paternally at 6, but not 16, weeks

cardiovascular system
• decreased vascularity when the allele is inherited paternally





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory