All Phenotypes Nlrp1a<Neut1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlrp1a^Neut1
neutrophilia 1
MGI:5471965

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp1a^Neut1/Nlrp1a^Neut1	C.B6-Nlrp1a^Neut1	MGI:5472133
ht2	Nlrp1a^Neut1/Nlrp1a⁺	C.B6-Nlrp1a^Neut1	MGI:5472132
cx3	Il18^tm1Aki/Il18^tm1Aki Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129P2/OlaHsd * C57BL/6	MGI:5474287
cx4	Il1a^tm1Yiw/Il1a^tm1Yiw Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5474284
cx5	Nlrp1a^Neut1/Nlrp1a^Neut1 Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5474286
cx6	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S1/Sv * C57BL/6	MGI:5474283
cx7	Casp1^tm1Sesh/Casp1^tm1Sesh Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S2/SvPas * C57BL/6	MGI:5474285
cx8	Ighm^tm1Cgn/Ighm^tm1Cgn Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S2/SvPas * C57BL/6	MGI:5474290
cx9	Ifng^tm1Ts/Ifng^tm1Ts Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S7/SvEvBrd * C57BL/6	MGI:5474288
cx10	Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1	involves: C57BL/6	MGI:5474289

Allelic Composition	Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	C.B6-Nlrp1a^Neut1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:191055 )

• lethal by 3-5 months of age

growth/size/body

enlarged spleen ( J:191055 )

immune system

enlarged spleen ( J:191055 )

increased neutrophil cell number ( J:191055 )

• neutrophile count 15 fold higher than controls

decreased lymphocyte cell number ( J:191055 )

decreased macrophage cell number ( J:191055 )

• loss of peritoneal macrophage

increased macrophage cytokine production ( J:191055 )

• macrophage primed only with lipopolysaccharide secrete significant amounts of IL-1beta

increased inflammatory response ( J:191055 )

• otherwise appears healthy at 8 months of age

• multi-organ neutrophilic inflammatory disease

• inflammatory bowel disease

myocarditis ( J:191055 )

pancreas inflammation ( J:191055 )

meningitis ( J:191055 )

liver inflammation ( J:191055 )

lung inflammation ( J:191055 )

• pneumonitis

• pulmonary peri-arteritis

cardiovascular system

myocarditis ( J:191055 )

endocrine/exocrine glands

pancreas inflammation ( J:191055 )

liver/biliary system

liver inflammation ( J:191055 )

nervous system

meningitis ( J:191055 )

reproductive system

reproductive system phenotype ( J:191055 )

• fertile

respiratory system

lung inflammation ( J:191055 )

• pneumonitis

• pulmonary peri-arteritis

hematopoietic system

enlarged spleen ( J:191055 )

increased neutrophil cell number ( J:191055 )

• neutrophile count 15 fold higher than controls

decreased lymphocyte cell number ( J:191055 )

decreased macrophage cell number ( J:191055 )

• loss of peritoneal macrophage

increased macrophage cytokine production ( J:191055 )

• macrophage primed only with lipopolysaccharide secrete significant amounts of IL-1beta

Allelic Composition	Nlrp1a^Neut1/Nlrp1a⁺
Genetic Background	C.B6-Nlrp1a^Neut1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased inflammatory response ( J:191055 )

• multi-organ neutrophilic inflammatory disease

• otherwise appears healthy at 8 months of age

• inflammatory bowel disease

myocarditis ( J:191055 )

pancreas inflammation ( J:191055 )

meningitis ( J:191055 )

liver inflammation ( J:191055 )

lung inflammation ( J:191055 )

• pneumonitis

• pulmonary peri-arteritis

reproductive system

reproductive system phenotype ( J:191055 )

• fertile

nervous system

meningitis ( J:191055 )

liver/biliary system

liver inflammation ( J:191055 )

respiratory system

lung inflammation ( J:191055 )

• pneumonitis

• pulmonary peri-arteritis

endocrine/exocrine glands

pancreas inflammation ( J:191055 )

cardiovascular system

myocarditis ( J:191055 )

Allelic Composition	Il18^tm1Aki/Il18^tm1Aki Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il18^tm1Aki mutation (3 available); any Il18 mutation (32 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:191055 )

• succumb to inflammatory disease at 5-10 weeks of age

• normal mortality in a germ free environment

immune system

increased neutrophil cell number ( J:191055 )

• increased blood neutrophils

• no neutrophil infiltration of the liver

• neutrophile numbers are like controls in a germ free environment

abnormal inflammatory response ( J:191055 )

• accelerated onset of inflammatory disease

myocarditis ( J:191055 )

• increased frequency of myocarditis

hematopoietic system

increased neutrophil cell number ( J:191055 )

• increased blood neutrophils

• no neutrophil infiltration of the liver

• neutrophile numbers are like controls in a germ free environment

cardiovascular system

myocarditis ( J:191055 )

• increased frequency of myocarditis

Allelic Composition	Il1a^tm1Yiw/Il1a^tm1Yiw Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1a^tm1Yiw mutation (0 available); any Il1a mutation (30 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased neutrophil cell number ( J:191055 )

abnormal inflammatory response ( J:191055 )

• lethal systemic inflammatory disease

hematopoietic system

increased neutrophil cell number ( J:191055 )

Allelic Composition	Nlrp1a^Neut1/Nlrp1a^Neut1 Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:191055 )

immune system

increased neutrophil cell number ( J:191055 )

abnormal inflammatory response ( J:191055 )

• lethal systemic inflammatory disease

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:191055 )

N	• inflammatory disease does not develop

abnormal leukopoiesis ( J:191055 )

abnormal leukocyte cell number ( J:191055 )

decreased eosinophil cell number ( J:191055 )

decreased lymphocyte cell number ( J:191055 )

decreased monocyte cell number ( J:191055 )

increased susceptibility to Riboviria infection ( J:191055 )

• increased sensitivity to lymphocytic choriomeningitis virus although virus titers remain like controls

hematopoietic system

abnormal leukopoiesis ( J:191055 )

thrombocytopenia ( J:191055 )

abnormal leukocyte cell number ( J:191055 )

decreased eosinophil cell number ( J:191055 )

decreased lymphocyte cell number ( J:191055 )

decreased monocyte cell number ( J:191055 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191055 )

• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191055 )

• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

Allelic Composition	Casp1^tm1Sesh/Casp1^tm1Sesh Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Sesh mutation (5 available); any Casp1 mutation (42 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:191055 )

N	• no neutrophilia or inflammatory disease • no loss of macrophage progenitor cells

increased circulating interleukin-18 level ( J:191055 )

homeostasis/metabolism

increased circulating interleukin-18 level ( J:191055 )

Allelic Composition	Ighm^tm1Cgn/Ighm^tm1Cgn Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (17 available); any Ighm mutation (56 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:191055 )

N	• no abnormal neutrophil infiltration of the dermis

Allelic Composition	Ifng^tm1Ts/Ifng^tm1Ts Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifng^tm1Ts mutation (18 available); any Ifng mutation (49 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:191055 )

N	• normal blood neutrophils and survival

brain inflammation ( J:191055 )

• develop encephalitis

nervous system

brain inflammation ( J:191055 )

• develop encephalitis

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (54 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased neutrophil cell number ( J:191055 )

skin inflammation ( J:191055 )

• neutrophil infiltration of the dermis

increased susceptibility to infection induced morbidity/mortality ( J:191055 )

• reduction in disease free survival

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:191055 )

• reduction in disease free survival

hematopoietic system

increased neutrophil cell number ( J:191055 )

integument

skin inflammation ( J:191055 )

• neutrophil infiltration of the dermis

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