Phenotypes associated with this allele

• Allele Symbol: Zfp24^hmcns-2J
• Allele Name: hypomyelinated central nervous system 2 Jackson
• Allele ID: MGI:5472018
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp24^hmcns-2J/Zfp24^hmcns-2J	CByJ(Cg)-Zfp24^hmcns-2J/GrsrJ	MGI:5520084

Genotype
MGI:5520084

hm1

• Allelic Composition: Zfp24^hmcns-2J/Zfp24^hmcns-2J
• Genetic Background: CByJ(Cg)-Zfp24^hmcns-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

tonic seizures ( J:202595 )

• both female and male homozygotes have tonic seizures

decreased myelin sheath thickness ( J:202595 )

• at four weeks of age very little myelin is found in the central nervous system, but there is normal myelination in the peripheral nervous system

abnormal myelination ( J:202595 )

mortality/aging

premature death ( J:202595 )

• all homozygotes die by four to five weeks of age

behavior/neurological

tremors ( J:202595 )

• evident by 14 days of age, most apparent when moving, and increasing in severity until death before four to five weeks of age

tonic seizures ( J:202595 )

• both female and male homozygotes have tonic seizures

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:202595 )

• at four weeks of age 5 out of 7 homozygotes show elevated thresholds indicative of hearing loss

vision/eye

vision/eye phenotype ( J:202595 )

N • the eyes of four homozygotes at three weeks of age appeared normal by ophthalmascopy