Phenotypes associated with this allele

• Allele Symbol: Cd200r1^tm1Eakj
• Allele Name: targeted mutation 1, Evelyn A Kurt-Jones
• Allele ID: MGI:5472130
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd200r1^tm1Eakj/Cd200r1^tm1Eakj	Not Specified	MGI:5472134

Genotype
MGI:5472134

hm1

• Allelic Composition: Cd200r1^tm1Eakj/Cd200r1^tm1Eakj
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased susceptibility of Cd200r1^tm1Eakj/Cd200r1^tm1Eakj mice to HSV-1 viral infection

behavior/neurological

decreased mechanical nociceptive threshold ( J:326965 )

• mice fail to recovery from carrageenan-induced inflammatory hyperalgesia unlike wild-type mice

• however, mice do resolve carrageenan-induced inflammation

abnormal nociception after inflammation ( J:326965 )

• mice fail to recovery from carrageenan-induced inflammatory hyperalgesia unlike wild-type mice

mortality/aging

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:192198 )

• mice are protected from HSV-1 encephalitis and lethality

immune system

abnormal macrophage physiology ( J:326965 )

• macrophage mitochondria fail to transfer MTDR-labeled mitochondria to sensory neurons unlike wild-type mice

• however, mitochondria exhibit normal respiration and vesicle release

decreased interferon-beta secretion ( J:192198 )

• in the brains following HSV-1 infection

decreased interleukin-1 beta secretion ( J:192198 )

• from peritoneal or bone-marrow macrophages stimulated with HSV-1

• however, secretion after ATP stimulation is normal

decreased interleukin-6 secretion ( J:192198 )

• from macrophages stimulated with HSV-1, Pam2CSK4 or LPS

decreased susceptibility to Herpesvirales infection ( J:192198 )

• mice are protected from HSV-1 encephalitis and lethality with reduced type I IFN production and lower viral titers mouse due to reduced viral replication and more efficient clearance

• mouse embryonic fibroblasts and peritoneal macrophages infected with HSV-1 exhibit reduced infection ex vivo

• however, IL-6 and chemokine (CCL5 and CCL2) levels in the brain are the same as in injected wild-type mice

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:192198 )

• mice are protected from HSV-1 encephalitis and lethality

hematopoietic system

abnormal macrophage physiology ( J:326965 )

• macrophage mitochondria fail to transfer MTDR-labeled mitochondria to sensory neurons unlike wild-type mice

• however, mitochondria exhibit normal respiration and vesicle release