Phenotypes associated with this allele

• Allele Symbol: Alkal2^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5472661
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alkal2^tm1a(EUCOMM)Hmgu/Alkal2^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:7660946

Genotype
MGI:7660946

hm1

• Allelic Composition: Alkal2^{tm1a(EUCOMM)Hmgu}/Alkal2^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:324631 )

• mice are significantly leaner than wild-type or heterozygous controls from the age of 14 weeks onward

decreased body weight ( J:324631 )

• mice fed a standard chow diet show a significantly lower body weight than wild-type or heterozygous controls at 36 and 52 weeks of age

slow postnatal weight gain ( J:324631 )

• male and female mice fed a standard chow diet gain less weight than wild-type or heterozygous controls from the age of 4 weeks onward

decreased susceptibility to diet-induced obesity ( J:324631 )

• mice fed a high-fat diet (HFD) gain significantly less weight than similarly fed wild-type or heterozygous controls, suggesting resistance to HFD-induced weight gain

thin body ( J:324631 )

• mice fed a standard chow diet are thin, showing a marked reduction in their circumference but no change in body length

behavior/neurological

hyperactivity ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet are slightly more active during daytime but show a significantly higher physical activity during nighttime

adipose tissue

decreased subcutaneous adipose tissue amount ( J:324631 )

• subcutaneous WAT weight is significantly lower than in wild-type controls

decreased white adipose tissue amount ( J:324631 )

• mice exhibit a significant reduction in the size of white adipose tissue (WAT) depots

• however, the weight of fat mass from brown adipose tissue (BAT) is not significantly altered

decreased white fat cell size ( J:324631 )

• mice exhibit a higher percentage of small adipocytes in gonadal, retroperitoneal and subcutaneous WAT

decreased gonadal fat pad weight ( J:324631 )

• gonadal WAT weight is significantly lower than in wild-type controls

decreased retroperitoneal fat pad weight ( J:324631 )

• retroperitoneal WAT weight is significantly lower than in wild-type controls

decreased percent body fat/body weight ( J:324631 )

• adult mice fed a standard chow diet show a significant decrease in overall body fat with respect to overall body weight

browned white adipose tissue morphology ( J:324631 )

• qRT-PCR analysis showed increased expression levels of Ucp1, Ppargc1a, Cidea, and Adrb3 in WAT depots, suggesting some browning of WAT

homeostasis/metabolism

increased noradrenaline level ( J:324631 )

• mice exhibit a significant increase of norepinephrine levels in subcutaneous WAT

increased energy expenditure ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet show significantly increased energy expenditure (EE) during nighttime; total EE is also significantly increased

decreased susceptibility to diet-induced obesity ( J:324631 )

• mice fed a high-fat diet (HFD) gain significantly less weight than similarly fed wild-type or heterozygous controls, suggesting resistance to HFD-induced weight gain

increased carbon dioxide production ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet show a significantly greater CO₂ production during nighttime; total CO₂ production is also significantly increased

increased oxygen consumption ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet show a significantly greater oxygen consumption during nighttime; total oxygen consumption is also significantly increased

increased respiratory quotient ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet show a significantly higher RER during nighttime

improved glucose tolerance ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet show improved glucose tolerance

increased insulin sensitivity ( J:324631 )

• 3- to 6-mo-old mice fed a standard chow diet show increased sensitivity to insulin

integument

decreased subcutaneous adipose tissue amount ( J:324631 )

• subcutaneous WAT weight is significantly lower than in wild-type controls