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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn
transgene insertion 1, Weiyong Shen
MGI:5473306
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(DTA)Mrc/?
Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA MGI:5491505


Genotype
MGI:5491505
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Mrc/?
Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Muller cell loss results in breakdown of the blood-retinal barrier 1-2 weeks after tamoxifen treatment; intense areas of focal vascular leak develop after 2 months, and persisting for at least 5 months
• retinal vascular permeability increases by 125% relative to controls after 2 doses of tamoxifen, and by 189% after 5 doses
• after tamoxifen administration, Muller cell loss is detected within 1 day; retinopathy develops subsequently
• 2 weeks after tamoxifen treatment, protrusion of photoreceptor cell bodies into the subretinal space is observed in areas of Muller cell loss
• 7 days after tamoxifen treatment, tortuous retinal vessels are observed at all three levels of the retinal vascular network
• vascular telangiectasis develops by 7 days after treatment, and vascular tufts are observed from 2 months after treatment
• 2 months following tamoxifen treatment, abnormal vessels appear in the deep retina; new vessels originate from the inner retina
• after tamoxifen administration, Muller cell loss is detected within 1 day
• patchy loss of cone photoreceptor outer segments is after tamoxifen treatment; this proceeds for 14 days, then stabilizes 28 days after tamoxifen induction
• in areas of Muller cell loss 2 weeks after tamoxifen treatment
• in regions of neovascularization, RPE clumping, proliferation and migration into regions of the new vessels are observed
• 2 weeks after tamoxifen treatment, loss of the electron-dense end feet of Muller cells occurs, with loss of Muller cell bodies
• appears disorganized in areas of Muller cell loss 2 weeks after tamoxifen treatment
• 6 weeks after tamoxifen treatment, a- and b-wave responses are significantly reduced compared to controls; both rod- and cone-derived b-waves are affected
• in areas of Muller cell loss 2 weeks after tamoxifen treatment

nervous system
• after tamoxifen administration, Muller cell loss is detected within 1 day
• patchy loss of cone photoreceptor outer segments is after tamoxifen treatment; this proceeds for 14 days, then stabilizes 28 days after tamoxifen induction
• in areas of Muller cell loss 2 weeks after tamoxifen treatment
• Muller cell loss results in breakdown of the blood-retinal barrier 1-2 weeks after tamoxifen treatment; intense areas of focal vascular leak develop after 2 months, and persisting for at least 5 months
• retinal vascular permeability increases by 125% relative to controls after 2 doses of tamoxifen, and by 189% after 5 doses

cardiovascular system
• 7 days after tamoxifen treatment, tortuous retinal vessels are observed at all three levels of the retinal vascular network
• vascular telangiectasis develops by 7 days after treatment, and vascular tufts are observed from 2 months after treatment
• 2 months following tamoxifen treatment, abnormal vessels appear in the deep retina; new vessels originate from the inner retina

pigmentation
• in regions of neovascularization, RPE clumping, proliferation and migration into regions of the new vessels are observed





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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory