Analysis Tools
vision/eye
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• Muller cell loss results in breakdown of the blood-retinal barrier 1-2 weeks after tamoxifen treatment; intense areas of focal vascular leak develop after 2 months, and persisting for at least 5 months
• retinal vascular permeability increases by 125% relative to controls after 2 doses of tamoxifen, and by 189% after 5 doses
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• after tamoxifen administration, Muller cell loss is detected within 1 day; retinopathy develops subsequently
• 2 weeks after tamoxifen treatment, protrusion of photoreceptor cell bodies into the subretinal space is observed in areas of Muller cell loss
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• 7 days after tamoxifen treatment, tortuous retinal vessels are observed at all three levels of the retinal vascular network
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• vascular telangiectasis develops by 7 days after treatment, and vascular tufts are observed from 2 months after treatment
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• 2 months following tamoxifen treatment, abnormal vessels appear in the deep retina; new vessels originate from the inner retina
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• after tamoxifen administration, Muller cell loss is detected within 1 day
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• patchy loss of cone photoreceptor outer segments is after tamoxifen treatment; this proceeds for 14 days, then stabilizes 28 days after tamoxifen induction
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• in areas of Muller cell loss 2 weeks after tamoxifen treatment
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• in regions of neovascularization, RPE clumping, proliferation and migration into regions of the new vessels are observed
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• 2 weeks after tamoxifen treatment, loss of the electron-dense end feet of Muller cells occurs, with loss of Muller cell bodies
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• appears disorganized in areas of Muller cell loss 2 weeks after tamoxifen treatment
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• 6 weeks after tamoxifen treatment, a- and b-wave responses are significantly reduced compared to controls; both rod- and cone-derived b-waves are affected
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• in areas of Muller cell loss 2 weeks after tamoxifen treatment
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nervous system
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• after tamoxifen administration, Muller cell loss is detected within 1 day
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• patchy loss of cone photoreceptor outer segments is after tamoxifen treatment; this proceeds for 14 days, then stabilizes 28 days after tamoxifen induction
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• in areas of Muller cell loss 2 weeks after tamoxifen treatment
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• Muller cell loss results in breakdown of the blood-retinal barrier 1-2 weeks after tamoxifen treatment; intense areas of focal vascular leak develop after 2 months, and persisting for at least 5 months
• retinal vascular permeability increases by 125% relative to controls after 2 doses of tamoxifen, and by 189% after 5 doses
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cardiovascular system
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• 7 days after tamoxifen treatment, tortuous retinal vessels are observed at all three levels of the retinal vascular network
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• vascular telangiectasis develops by 7 days after treatment, and vascular tufts are observed from 2 months after treatment
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• 2 months following tamoxifen treatment, abnormal vessels appear in the deep retina; new vessels originate from the inner retina
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pigmentation
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• in regions of neovascularization, RPE clumping, proliferation and migration into regions of the new vessels are observed
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