Phenotypes associated with this allele

• Allele Symbol: Otx2^{tm1.1(cre/ERT2)Mgoe}
• Allele Name: targeted mutation 1.1, Magdalena Goetz
• Allele ID: MGI:5473314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Otx2^tm1.1(cre/ERT2)Mgoe/Otx2^tm6Asim Tg(CAG-cat,-EGFP)1Rbns/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5473338

Genotype
MGI:5473338

cn1

• Allelic Composition: Otx2^{tm1.1(cre/ERT2)Mgoe}/Otx2^tm6Asim; Tg(CAG-cat,-EGFP)1Rbns/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal choroid plexus morphology ( J:194049 )

• when tamoxifen is given on E15, choroid epithelial cells as well as the entire structures appear unaltered in size; however, at P7, fourth ventricular choroid plexus is much smaller (decreased rostrocaudally, not lateral to medial) compared to controls

absent choroid plexus ( J:194049 )

• with tamoxifen induction on E9 of gestation, the four choroid plexuses in the forebrain (including the third ventricular choroid plexus anlage) and hindbrain are virtually absent in E13 embryos; in some embryos a small remnant is found caudally but this tissue is not transthyretin-positive as expected