Analysis Tools|
Allele Symbol Allele Name Allele ID |
Plvaptm1.2Rvst targeted mutation 1.2, Radu V Stan MGI:5473518 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: display 100% lethality between E13 and P2 on a congenic C57BL/6 background unlike mice on a mixed 129S4/SvJae, BALB/c, C57BL/6, and SJL where about 20% of mice survive to 3-4 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: mice on a mixed background are found at about 20% the expected frequency at 3-4 months of age, unlike mice on a congenic C57BL/6 background that all die by P2
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• caveolae stomatal diaphragms are absent from the lung, adrenals, pancreas, pituitary, thyroid, kidney, intestinal villi, and liver
• however, in the lung the surface density of endothelial cell caveolae is similar to controls
• diaphragms are absent from all fenestrae and transendothelial channels in all fenestrated capillaries in the adrenals, pancreas, intestine, choroid plexus, pituitary, thyroid and kidney peritubular capillaries
• fenestral pores display a larger variation of diameter
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• caveolae stomatal diaphragms are absent from the capillaries in the lung
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• caveolae stomatal diaphragms are absent from the lung, adrenals, pancreas, pituitary, thyroid, kidney, intestinal villi, and liver
• however, in the lung the surface density of endothelial cell caveolae is similar to controls
• diaphragms are absent from all fenestrae and transendothelial channels in all fenestrated capillaries in the adrenals, pancreas, intestine, choroid plexus, pituitary, thyroid and kidney peritubular capillaries
• passage of albumin-coated gold nanoparticles of 10, 15, and 25 nm indicate an increase in pore size in adrenal capillaries
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• absence of diaphragms from all fenestrae in all fenestrated capillaries
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• leakage of Evans Blue dye is dramatically increased in organs with fenestrated endothelial cells
• leakage of Evans Blue dye is highest in the intestine with minimal increases in the lungs and heart and no change in the liver
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• dramatic increase in chylomicrons remnants/very low-density lipoproteins
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• sharp decrease in total plasma protein, albumin, and albumin/globulin ratio
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• sharp decrease in total plasma protein, albumin, and albumin/globulin ratio
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• at 3-4 weeks of age organs with fenestrated vessels (intestine, kidney and pancreas) show signs of edema
• edema is not due to inflammation
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• at 3-4 weeks of age
• intestinal villi are distended with protein containing material accumulating between the enterocytes and stroma
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• fluid contains albumin and beta globins at similar levels to blood plasma but sharply reduced alpha fractions
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• significantly decreased at 4 weeks of age and does not vary much with time
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• moderate increase at 4 weeks of age that does not vary much with time
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• starting after 2 weeks of age and becoming more severe with age
• plasma levels are increased up to 5000?6000 mg/dl from 4 to 8 weeks of age
• after 8 weeks of age several tissues lipids are seen engorging the capillaries
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• on the surface of the heart and liver after 8 weeks of age
• perivascular lipid deposits are seen at 10-12 weeks of age
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• at 3-4 weeks of age
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• at 3-4 weeks of age
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• at 3-4 weeks of age
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• about a 30-40% reduction in body weight at 4 weeks of age
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• about a 15% decrease at 4 weeks of age
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• similar in size to controls at birth but gradually develop signs of growth retardation
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• due to accumulation of ascites
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• in mice over 1 week of age
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• bent tail
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| N |
• no protein is detected in the urine between birth and 12 weeks of age
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• absence of diaphragms from all fenestrae in all fenestrated capillaries
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• caveolae stomatal diaphragms are absent from the capillaries in the lung
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• at 3-4 weeks of age
• intestinal villi are distended with protein containing material accumulating between the enterocytes and stroma
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• at 3-4 weeks of age
• intestinal villi are distended with protein containing material accumulating between the enterocytes and stroma
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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