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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcm4Sdla
Spontaneous dominant leukemia
MGI:5473704
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mcm4Sdla/Mcm4Sdla involves: C57BL/6 MGI:5473715
ht2
 		Mcm4Sdla/Mcm4+ involves: C57BL/6 MGI:5473713
ht3
 		Mcm4chaos3/Mcm4Sdla involves: C57BL/6 * C57BL/6J MGI:5473714


Genotype
MGI:5473715
hm1
Allelic
Composition		 Mcm4Sdla/Mcm4Sdla
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Sdla mutation (0 available); any Mcm4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:194117 )
• no mice are present as early as E8.5




Genotype
MGI:5473713
ht2
Allelic
Composition		 Mcm4Sdla/Mcm4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Sdla mutation (0 available); any Mcm4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:194117 )
• in moribund mice
enlarged lymph nodes ( J:194117 )
• in moribund mice

neoplasm
increased tumor incidence ( J:194117 )
• hematologic malignancy including mediastinal masses, splenomegaly and/or lymphadenopathy in 180 of 191 moribund mice
increased acute lymphoblastic leukemia incidence ( J:194117 )
• early onset T cell acute lymphoblastic leukemia (T-ALL)

cellular
induced chromosome breakage ( J:194117 )
• in mouse embryonic fibroblasts in the presence or absence of aphidicolin
spontaneous chromosome breakage ( J:194117 )
• in mouse embryonic fibroblasts in the presence or absence of aphidicolin

hematopoietic system
enlarged spleen ( J:194117 )
• in moribund mice
reticulocytosis ( J:194117 )
• 18-fold increase in micronucleated reticulocytes

endocrine/exocrine glands

growth/size/body
enlarged spleen ( J:194117 )
• in moribund mice




Genotype
MGI:5473714
ht3
Allelic
Composition		 Mcm4chaos3/Mcm4Sdla
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4chaos3 mutation (1 available); any Mcm4 mutation (43 available)
Mcm4Sdla mutation (0 available); any Mcm4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:194117 )
• no mice are present at P1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory