mortality/aging
• all mice are dead by 60 weeks
|
• the first mice die at P14 and more than half of mice die by P21
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liver/biliary system
N |
• mice exhibit normal liver structure at P0
|
• 3 times in controls
|
• at P7, mice exhibit increased immature cholangiocyte-like and oval cells that becomes massive at P10 especially in periductal and intraductal locations
• mild hepatocholangiocellular hyperplasia at P21
|
• massive
|
• 5 times greater than in control mice at P14
|
• combined hepatocellular and cholangiocarcinomas, increased hepatocellular carcinoma, liver adenoma incidence or cholangiocarcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks
• combined hepatocellular and cholangiocarcinomas in 13 of 22 mice at week 60
• with lung metastasis after 40 weeks of age
|
• intrahepatic cholangiocellular carcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks
• in 2 of 22 mice at week 60
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• in mice surviving beyond P21 by age 15 weeks
• in 4 of 22 mice at week 60
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• in mice surviving beyond P21 by age 15 weeks
|
• cholangiocytes proliferation is increased 4 times compared with controls
• however, there is no increase in apoptosis
|
neoplasm
• with lung metastasis after 40 weeks of age
• combined hepatocellular and cholangiocarcinomas, increased hepatocellular carcinoma, liver adenoma incidence or cholangiocarcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks
• combined hepatocellular and cholangiocarcinomas in 13 of 22 mice at week 60
|
• intrahepatic cholangiocellular carcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks
• in 2 of 22 mice at week 60
|
• in mice surviving beyond P21 by age 15 weeks
• in 4 of 22 mice at week 60
|
• in mice surviving beyond P21 by age 15 weeks
|
homeostasis/metabolism
integument
• due to enlarged liver
|
cellular
• 3 times in controls
|
endocrine/exocrine glands
• at P7, mice exhibit increased immature cholangiocyte-like and oval cells that becomes massive at P10 especially in periductal and intraductal locations
• mild hepatocholangiocellular hyperplasia at P21
|
• intrahepatic cholangiocellular carcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks
• in 2 of 22 mice at week 60
|
growth/size/body
• massive
|