Phenotypes associated with this allele

• Allele Symbol: Mob1a^tm1.2Asuz
• Allele Name: targeted mutation 1.2, Akira Suzuki
• Allele ID: MGI:5473805
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5473843
cx2	Mob1a^tm1.2Asuz/Mob1a^+ Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5473844
cx3	Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5473845

Genotype
MGI:5473843

cx1

• Allelic Composition: Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tumorgenesis in Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺ or Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} mice

neoplasm

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased liver tumor incidence ( J:193981 )

• in half of mice

increased fibrosarcoma incidence ( J:193981 )

• in myofibrosarcomas some mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased integument system tumor incidence ( J:193981 )

• mice develop malignant outer root sheath tumors resembling trichilemmal carcinomas

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

increased lung tumor incidence ( J:193981 )

• in some mice

skeleton

malocclusion ( J:193981 )

• in half of mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased trabecular bone thickness ( J:193981 )

• in the femur of some mice

exostosis ( J:193981 )

• in the calvaria of most mice

integument

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

hearing/vestibular/ear

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

behavior/neurological

impaired balance ( J:193981 )

• in some mice due to disorganized inner ear hair bundles in the cochlear organ of Corti

craniofacial

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

nervous system

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

respiratory system

increased lung tumor incidence ( J:193981 )

• in some mice

growth/size/body

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

digestive/alimentary system

increased salivary gland tumor incidence ( J:193981 )

• in some mice

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased mammary gland tumor incidence ( J:193981 )

• in some mice

liver/biliary system

increased liver tumor incidence ( J:193981 )

• in half of mice

Genotype
MGI:5473844

cx2

• Allelic Composition: Mob1a^tm1.2Asuz/Mob1a⁺; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Tumorgenesis in Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺ or Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} mice

neoplasm

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased fibrosarcoma incidence ( J:193981 )

• in myofibrosarcomas some mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased integument system tumor incidence ( J:193981 )

• mice develop malignant outer root sheath tumors resembling trichilemmal carcinomas

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

skeleton

malocclusion ( J:193981 )

• in half of mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased trabecular bone thickness ( J:193981 )

• in the femur of some mice

exostosis ( J:193981 )

• in the calvaria of most mice

integument

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

hearing/vestibular/ear

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

craniofacial

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

behavior/neurological

impaired balance ( J:193981 )

• in some mice due to disorganized inner ear hair bundles in the cochlear organ of Corti

nervous system

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased mammary gland tumor incidence ( J:193981 )

• in some mice

digestive/alimentary system

increased salivary gland tumor incidence ( J:193981 )

• in some mice

growth/size/body

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

Genotype
MGI:5473845

cx3

• Allelic Composition: Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:193981 )

• despite decidua formation, mice are absorbed by E6.5

cellular

abnormal cell nucleus morphology ( J:193981 )

• micronuclei in mouse embryonic fibroblasts

abnormal mitosis ( J:193981 )

• in mouse embryonic fibroblasts

absent inner cell mass proliferation ( J:193981 )

• after 8 days in culture, E3.5 embryos exhibit growth failure of the inner cell mass

• however, the trophoectoderm develops normally

embryo

absent inner cell mass proliferation ( J:193981 )

• after 8 days in culture, E3.5 embryos exhibit growth failure of the inner cell mass

• however, the trophoectoderm develops normally