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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptp4a3tm1.1Geh
targeted mutation 1.1, Gregg E Homanics
MGI:5473867
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptp4a3tm1.1Geh/Ptp4a3tm1.1Geh involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5473976


Genotype
MGI:5473976
hm1
Allelic
Composition		 Ptp4a3tm1.1Geh/Ptp4a3tm1.1Geh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a3tm1.1Geh mutation (0 available); any Ptp4a3 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
decreased incidence of tumors by chemical induction ( J:194458 )
• in a model of colitis-associated colon cancer, mice treated with AOM and DDS develop fewer intestinal tumors at 12 weeks post-treatment compared with control mice
decreased tumor growth/size ( J:194458 )
• no increase in tumor size or number between 12 and 16 weeks in mice treated with AOM and DDS

growth/size/body
decreased body mass index ( J:194458 )
• at 6 weeks in male, but not female, mice
decreased body weight ( J:194458 )
• at 6 weeks in male, but not female, mice

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:194458 )
• in a model of colitis-associated colon cancer, mice treated with AOM and DDS develop fewer intestinal tumors at 12 weeks post-treatment compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory