digestive/alimentary system
• suppressed cellular differentiation toward goblet cells
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• after doxycycline treatment of adults
• number of intestinal stem cells is increased
• decreased cell division in colonic cells
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• crypt fission and budding is normalized after treatment with notch inhibitors
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• crypt fission is often observed in the large intestine
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• crypt fission is often observed in the small intestine
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endocrine/exocrine glands
• crypt fission and budding is normalized after treatment with notch inhibitors
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• crypt fission is often observed in the large intestine
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• crypt fission is often observed in the small intestine
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cellular
• suppressed cellular differentiation toward goblet cells
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