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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col1a1tm2(tetO-CTNNB1*)Hoch
targeted mutation 2, Konrad Hochedlinger
MGI:5473958
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Col1a1tm2(tetO-CTNNB1*)Hoch/Col1a1tm2(tetO-CTNNB1*)Hoch
Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
involves: 129S4/SvJae * C57BL/6 MGI:5474007


Genotype
MGI:5474007
cx1
Allelic
Composition
Col1a1tm2(tetO-CTNNB1*)Hoch/Col1a1tm2(tetO-CTNNB1*)Hoch
Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-CTNNB1*)Hoch mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• suppressed cellular differentiation toward goblet cells
• after doxycycline treatment of adults
• number of intestinal stem cells is increased
• decreased cell division in colonic cells
• crypt fission and budding is normalized after treatment with notch inhibitors
• crypt fission is often observed in the large intestine
• crypt fission is often observed in the small intestine

endocrine/exocrine glands
• crypt fission and budding is normalized after treatment with notch inhibitors
• crypt fission is often observed in the large intestine
• crypt fission is often observed in the small intestine

cellular
• suppressed cellular differentiation toward goblet cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory