Phenotypes associated with this allele

• Allele Symbol: Tg(Tagln-SLC6A4)#Edd
• Allele Name: transgene insertion, Saadia Eddahibi
• Allele ID: MGI:5474459
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Tagln-SLC6A4)#Edd/?	Not Specified	MGI:5474460

Genotype
MGI:5474460

tg1

• Allelic Composition: Tg(Tagln-SLC6A4)#Edd/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal lung vasculature morphology ( J:144126 )

• mutants develop marked pulmonary vascular remodeling as indicated by increased density of muscularized pulmonary vessels

• the increased density of muscularized pulmonary vessels becomes more prominent with time

• mutants show an increase in proliferation of smooth muscle cells in distal pulmonary vessel walls

abnormal vascular smooth muscle morphology ( J:144126 )

• mutants show an increase in proliferation of smooth muscle cells in distal pulmonary vessel walls

heart right ventricle hypertrophy ( J:144126 )

• right ventricle to left ventricle and septum weight ratio is increased indicating right ventricle hypertrophy

increased right ventricle systolic pressure ( J:144126 )

• right ventricular systolic pressure is increased

• however, systemic arterial pressure and heart rate are normal

pulmonary hypertension ( J:144126 )

• right ventricular systolic pressure and right ventricle to left ventricle and septum weight ratio is increased indicating presence of sustained pulmonary hypertension

• pulmonary hypertension progression gets worse over time

• 20 week old mutants exposed to an acute hypoxic challenge (8% oxygen) do not exhibit the marked increase in right ventricular systolic pressure that is seen in wild-type mice, indicating depressed hypoxic pulmonary vasoconstriction

• 8 week old mutants exposed to chronic hypoxia (10% oxygen) exhibit a more severe increase of right ventricle systolic pressure and degree of right ventricle hypertrophy and distal pulmonary vessel muscularization than wild-type mice

muscle

abnormal vascular smooth muscle morphology ( J:144126 )

• mutants show an increase in proliferation of smooth muscle cells in distal pulmonary vessel walls

heart right ventricle hypertrophy ( J:144126 )

• right ventricle to left ventricle and septum weight ratio is increased indicating right ventricle hypertrophy

respiratory system

abnormal lung vasculature morphology ( J:144126 )

• mutants develop marked pulmonary vascular remodeling as indicated by increased density of muscularized pulmonary vessels

• the increased density of muscularized pulmonary vessels becomes more prominent with time

• mutants show an increase in proliferation of smooth muscle cells in distal pulmonary vessel walls

growth/size/body

heart right ventricle hypertrophy ( J:144126 )

• right ventricle to left ventricle and septum weight ratio is increased indicating right ventricle hypertrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary pulmonary hypertension		DOID:14557	OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344	J:144126