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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpc5tm1.1Lbi
targeted mutation 1.1, Lutz Birnbaumer
MGI:5474572
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpc5tm1.1Lbi/Trpc5tm1.1Lbi involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5474573
ot2
 		Trpc5tm1.1Lbi/Y involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5474574


Genotype
MGI:5474573
hm1
Allelic
Composition		 Trpc5tm1.1Lbi/Trpc5tm1.1Lbi
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc5tm1.1Lbi mutation (1 available); any Trpc5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:194590 )
N
• spatial learning is similar to controls
decreased susceptibility to pharmacologically induced seizures ( J:194590 )
• decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:194590 )
• decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls
decreased susceptibility to neuronal excitotoxicity ( J:194590 )
• marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures
reduced long-term potentiation ( J:194590 )
• decrease in the potentiation of the fEPSP slope following high-frequency stimulus at Schaffer collateral synapses in the CA1 region

cellular
decreased susceptibility to neuronal excitotoxicity ( J:194590 )
• marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:194590 )
• marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures




Genotype
MGI:5474574
ot2
Allelic
Composition		 Trpc5tm1.1Lbi/Y
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc5tm1.1Lbi mutation (1 available); any Trpc5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:194590 )
N
• spatial learning is similar to controls
decreased susceptibility to pharmacologically induced seizures ( J:194590 )
• decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:194590 )
• decrease in the severity of the late phase of pilocarpine induced seizures but the early phase is similar to controls
decreased susceptibility to neuronal excitotoxicity ( J:194590 )
• marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures
reduced long-term potentiation ( J:194590 )
• decrease in the potentiation of the fEPSP slope following high-frequency stimulus at Schaffer collateral synapses in the CA1 region

cellular
decreased susceptibility to neuronal excitotoxicity ( J:194590 )
• marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:194590 )
• marked decrease in neuronal cell death in the hippocampus following pilocarpine induced seizures




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory