Phenotypes associated with this allele

• Allele Symbol: Emv72^b
• Allele Name: endogenous ecotropic MuLV 72, absent
• Allele ID: MGI:5474624
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Emv72^b/Emv72^b	CAnNCr.B6NCr-Emv72^b	MGI:5474628
hm2	Emv72^b/Emv72^b	involves: BALB/cAnNCr * C57BL/6NCr	MGI:5474629

Genotype
MGI:5474628

hm1

• Allelic Composition: Emv72^b/Emv72^b
• Genetic Background: CAnNCr.B6NCr-Emv72^b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell morphology ( J:194735 )

• mice exhibit increased numbers and avidity of responding antigen-specific T cells after vaccination with tumor-associated antigen

abnormal cytotoxic T cell physiology ( J:194735 )

• mice exhibit increased quantity and quality AH1-specifc T cell response compared with Emv72^a mice

neoplasm

decreased tumor growth/size ( J:194735 )

• only half of mice injected CT26 tumors cells develop tumors compared with most Emv72^a mice

• however, depletion of CD4+ of CD8+ T cells increases tumor development

hematopoietic system

abnormal T cell morphology ( J:194735 )

• mice exhibit increased numbers and avidity of responding antigen-specific T cells after vaccination with tumor-associated antigen

abnormal cytotoxic T cell physiology ( J:194735 )

• mice exhibit increased quantity and quality AH1-specifc T cell response compared with Emv72^a mice

Genotype
MGI:5474629

hm2

• Allelic Composition: Emv72^b/Emv72^b
• Genetic Background: involves: BALB/cAnNCr * C57BL/6NCr

immune system

abnormal cytotoxic T cell physiology ( J:194735 )

• T cells exhibit increased CT26 cell lysis (AH1 antigen) compared with cells from Emv72^a mice

hematopoietic system

abnormal cytotoxic T cell physiology ( J:194735 )

• T cells exhibit increased CT26 cell lysis (AH1 antigen) compared with cells from Emv72^a mice