Phenotypes associated with this allele

• Allele Symbol: Flvcr1^tm1Etol
• Allele Name: targeted mutation 1, Emanuela Tolosano
• Allele ID: MGI:5474636
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flvcr1^tm1Etol/Flvcr1^tm1Etol	either: (involves: 129) or (involves: 129 * C57BL/6)	MGI:5474646

Genotype
MGI:5474646

hm1

• Allelic Composition: Flvcr1^tm1Etol/Flvcr1^tm1Etol
• Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:194202 )

• mice die between E14.5 and birth with some dead newborns rarely present at birth

skeleton

abnormal skeleton morphology ( J:194202 )

• at E14.5

absent mandible ( J:194202 )

• at E14.5

abnormal cartilage morphology ( J:194202 )

• severely compromised head cartilage at E14.5

• incomplete nasal and Meckel's cartilage

small Meckel's cartilage ( J:194202 )

• reduced at E14.5

cardiovascular system

abnormal vascular development ( J:194202 )

• reduced vasculature extension and complexity, particularly in the primordial limb and tail

hemorrhage ( J:194202 )

• multifocal and extended at E12.5 and E15.5 in primordial limbs and throughout the head and body

craniofacial

small Meckel's cartilage ( J:194202 )

• reduced at E14.5

absent mandible ( J:194202 )

• at E14.5

hematopoietic system

hematopoietic system phenotype ( J:194202 )

N • fetal liver cells are able to reconstitute erythropoiesis when transplanted into lethally irradiated wild-type mice

homeostasis/metabolism

skin edema ( J:194202 )

• subcutaneous

integument

skin edema ( J:194202 )

• subcutaneous

limbs/digits/tail

abnormal digit development ( J:194202 )

• short digital cartilage at E14.5