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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr166tm4.1Wtg
targeted mutation 4.1, William Garrard
MGI:5474643
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr166tm4.1Wtg/Rr166tm4.1Wtg involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5475000
cx2
 		Igkctm1(IGKC)Mnz/Rr166tm4.1Wtg involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5475002


Genotype
MGI:5475000
hm1
Allelic
Composition		 Rr166tm4.1Wtg/Rr166tm4.1Wtg
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin light chain V-J recombination ( J:193015 )
• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones
• increased usage of Jkappa1 and decreased usage of Jkappa2
abnormal pre-B cell morphology ( J:193015 )
• pre-B cells show a less contracted and non-looped pattern in the nucleus
abnormal B cell physiology ( J:193015 )
• slightly increased percentage of Ig kappa expressing B cells
abnormal immunoglobulin level ( J:193015 )
• slightly increased percentage of Ig kappa expressing B cells
• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones
• increased usage of Jkappa1 and decreased usage of Jkappa2

hematopoietic system
abnormal immunoglobulin light chain V-J recombination ( J:193015 )
• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones
• increased usage of Jkappa1 and decreased usage of Jkappa2
abnormal pre-B cell morphology ( J:193015 )
• pre-B cells show a less contracted and non-looped pattern in the nucleus
abnormal B cell physiology ( J:193015 )
• slightly increased percentage of Ig kappa expressing B cells
abnormal immunoglobulin level ( J:193015 )
• slightly increased percentage of Ig kappa expressing B cells
• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones
• increased usage of Jkappa1 and decreased usage of Jkappa2




Genotype
MGI:5475002
cx2
Allelic
Composition		 Igkctm1(IGKC)Mnz/Rr166tm4.1Wtg
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Rr166tm4.1Wtg mutation (0 available); any Rr166 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele
abnormal immunoglobulin level ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele

hematopoietic system
abnormal B cell physiology ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele
abnormal immunoglobulin level ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory