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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabrg2tm2Spet
targeted mutation 2, Steven Petrou
MGI:5474655
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gabrg2tm2Spet/Gabrg2+ involves: 129S1/Sv * 129X1/SvJ MGI:5474681
cn2
 		Gabrg2tm2Spet/Gabrg2+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-cre)LC1Bjd/0 		involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 MGI:5474679


Genotype
MGI:5474681
ht1
Allelic
Composition		 Gabrg2tm2Spet/Gabrg2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Spet mutation (0 available); any Gabrg2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:194196 )
• induced by pentylenetetrazil compared with Gabrg2tm2Spet/Gabrg2+ Tg(Camk2a-tTA)1Mmay Tg(tetO-cre)LC1Bjd mice (no doxycycline treatment)
• however, no seizure kindling effect is observed

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:194196 )
• induced by pentylenetetrazil compared with Gabrg2tm2Spet/Gabrg2+ Tg(Camk2a-tTA)1Mmay Tg(tetO-cre)LC1Bjd mice (no doxycycline treatment)
• however, no seizure kindling effect is observed




Genotype
MGI:5474679
cn2
Allelic
Composition		 Gabrg2tm2Spet/Gabrg2+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-cre)LC1Bjd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Spet mutation (0 available); any Gabrg2 mutation (41 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:194736 )
• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed

nervous system
increased susceptibility to pharmacologically induced seizures ( J:194736 )
• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed




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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory