Phenotypes associated with this allele

• Allele Symbol: Pcsk5^{tm1b(KOMP)Mbp}
• Allele Name: targeted mutation 1b, Mouse Biology Program, UC Davis
• Allele ID: MGI:5474776
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcsk5^tm1b(KOMP)Mbp/Pcsk5^tm1b(KOMP)Mbp	C57BL/6N-Pcsk5^tm1b(KOMP)Mbp/J	MGI:5631393
ht2	Pcsk5^tm1b(KOMP)Mbp/Pcsk5^+	C57BL/6N-Pcsk5^tm1b(KOMP)Mbp/J	MGI:5757491

Genotype
MGI:5631393

hm1

• Allelic Composition: Pcsk5^{tm1b(KOMP)Mbp}/Pcsk5^{tm1b(KOMP)Mbp}
• Genetic Background: C57BL/6N-Pcsk5^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD00524_4_E10

Data Sources

IMPC Data for Pcsk5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:211773 )

IMPC - JAX

craniofacial

abnormal facial morphology ( J:211773 )

IMPC - JAX

cleft palate ( J:211773 )

IMPC - JAX

digestive/alimentary system

cleft palate ( J:211773 )

IMPC - JAX

embryo

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

abnormal limb bud morphology ( J:211773 )

♀

IMPC - JAX

abnormal neural tube closure ( J:211773 )

IMPC - JAX

growth/size/body

abnormal facial morphology ( J:211773 )

IMPC - JAX

cleft palate ( J:211773 )

IMPC - JAX

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

abnormal body wall morphology ( J:211773 )

IMPC - JAX

limbs/digits/tail

abnormal limb morphology ( J:211773 )

IMPC - JAX

abnormal limb bud morphology ( J:211773 )

♀

IMPC - JAX

abnormal tail morphology ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - JAX

Genotype
MGI:5757491

ht2

• Allelic Composition: Pcsk5^{tm1b(KOMP)Mbp}/Pcsk5⁺
• Genetic Background: C57BL/6N-Pcsk5^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD00524_4_E10

Data Sources

IMPC Data for Pcsk5

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - JAX

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - JAX

increased lean body mass ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - JAX

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - JAX

decreased circulating calcium level ( J:211773 )

♂

IMPC - JAX

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - JAX