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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Vil1-cre)1000Gum
transgene insertion 1000, Deborah L Gumucio
MGI:5474779
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atg5tm1Myok/Atg5tm1Myok
Tg(Vil1-cre)1000Gum/0 		involves: 129S/SvEv * C57BL/6J * SJL/J MGI:5569384
cn2
 		Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vil1-cre)1000Gum/0 		involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL/J MGI:5569387


Genotype
MGI:5569384
cn1
Allelic
Composition		 Atg5tm1Myok/Atg5tm1Myok
Tg(Vil1-cre)1000Gum/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5tm1Myok mutation (3 available); any Atg5 mutation (29 available)
Tg(Vil1-cre)1000Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:206181 )
• goblet cells exhibit increased mucin accumulation compared with control cells
• however, the number of goblet cells is normal and hydrogen peroxide treatment normalizes mucin levels

cellular
abnormal intestinal goblet cell morphology ( J:206181 )
• goblet cells exhibit increased mucin accumulation compared with control cells
• however, the number of goblet cells is normal and hydrogen peroxide treatment normalizes mucin levels




Genotype
MGI:5569387
cn2
Allelic
Composition		 Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vil1-cre)1000Gum/0
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Tg(Vil1-cre)1000Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:206181 )
• goblet cells exhibit increased mucin accumulation compared with control cells

cellular
abnormal intestinal goblet cell morphology ( J:206181 )
• goblet cells exhibit increased mucin accumulation compared with control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory