Phenotypes associated with this allele

• Allele Symbol: Pikfyve^tm1Tssk
• Allele Name: targeted mutation 1, Takehiko Sasaki
• Allele ID: MGI:5474980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pikfyve^tm1Tssk/Pikfyve^tm1Tssk	involves: 129P2/OlaHsd * C57BL/6	MGI:5474982

Genotype
MGI:5474982

hm1

• Allelic Composition: Pikfyve^tm1Tssk/Pikfyve^tm1Tssk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:193689 )

• embryos appear viable at E7.5 but are nonviable and undergoing tissue autolysis by E8.5

embryo

embryonic growth arrest ( J:193689 )

• stop growing at E7.0

decreased embryo size ( J:193689 )

• by E7.5

abnormal visceral endoderm morphology ( J:193689 )

• visceral endoderm cells are vacuolated at E5.5 - E6.5

• abnormal organization is seen at E6.5

• maternal IgE is abnormally bound to the apical surface of cells

abnormal visceral endoderm physiology ( J:193689 )

• decrease in endocytosis in the visceral endoderm at E6.2

growth/size/body

decreased embryo size ( J:193689 )

• by E7.5