Phenotypes associated with this allele

• Allele Symbol: Kcnk6^tm1Tigm
• Allele Name: targeted mutation 1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5474993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk6^tm1Tigm/Kcnk6^tm1Tigm	involves: 129S5/SvEvBrd * C57BL/6	MGI:5474997

Genotype
MGI:5474997

hm1

• Allelic Composition: Kcnk6^tm1Tigm/Kcnk6^tm1Tigm
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic vascular resistance ( J:194443 )

♂ • in anesthetized mice

hypertension ( J:194443 )

♂

increased mean systemic arterial blood pressure ( J:194443 )

♂ • in awake and anesthetized mice

increased systemic arterial diastolic blood pressure ( J:194443 )

♂ • in anesthetized mice

increased systemic arterial systolic blood pressure ( J:194443 )

♂ • in awake and anesthetized mice

abnormal vascular smooth muscle physiology ( J:194443 )

♂ • vascular smooth muscle cells are more depolarized than wild-type cells

♂ • however, vascular smooth muscle exhibits normal migration, proliferation, osmotic volume regulation and apoptotic volume regulation

abnormal vasoconstriction ( J:194443 )

♂

muscle

abnormal vascular smooth muscle physiology ( J:194443 )

♂ • vascular smooth muscle cells are more depolarized than wild-type cells

♂ • however, vascular smooth muscle exhibits normal migration, proliferation, osmotic volume regulation and apoptotic volume regulation

abnormal vasoconstriction ( J:194443 )

♂