Phenotypes associated with this allele

• Allele Symbol: Nr3c2^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5474998
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr3c2^tm1.1Ics/Nr3c2^tm1.1Ics Tg(Acta2-cre/ERT2)#Pcn/0	involves: 129S2/SvPas * FVB/N	MGI:5475012

Genotype
MGI:5475012

cn1

• Allelic Composition: Nr3c2^tm1.1Ics/Nr3c2^tm1.1Ics; Tg(Acta2-cre/ERT2)#Pcn/0
• Genetic Background: involves: 129S2/SvPas * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:193438 )

N • tamoxifen-treated mice exhibit normal vascular structure and blood pressure response to altered sodium content diets

decreased heart weight ( J:193438 )

• aged tamoxifen-treated mice do not develop cardiac hypertrophy unlike control mice

decreased systemic arterial systolic blood pressure ( J:193438 )

• in tamoxifen-treated mice by 7 months of age

• in adult and aged tamoxifen-treated mice in response to Ang II

• however, diurnal blood pressure variation is normal

abnormal vasoconstriction ( J:193438 )

• aged tamoxifen-treated mice fail to exhibit an increase in contraction response to KCL or U46619 (thromboxane receptor agonist) unlike control mice

• however, the age-dependent increase in contraction response to phenylephrine is preserved

decreased vasoconstriction ( J:193438 )

• in tamoxifen-treated mice in response to phenylephrine

• in adult tamoxifen-treated mice in response to acetylcholine

• in aged tamoxifen-treated mice in response to BayK8644 (L-type calcium channel agonist)

• in adult and aged tamoxifen-treated mice in response to Ang II

increased vasoconstriction ( J:193438 )

• in aged tamoxifen-treated mice in response to sodium nitroprusside

abnormal vasodilation ( J:193438 )

• aged tamoxifen-treated mice exhibit a modest decrease in endothelial cell-independent vasodilation compared with control mice

increased vasodilation ( J:193438 )

• endothelial-dependent tamoxifen-treated mice

renal/urinary system

renal/urinary system phenotype ( J:193438 )

N • tamoxifen-treated mice exhibit intact renal function

cellular

abnormal redox activity ( J:193438 )

• adult tamoxifen-treated mice exhibit attenuated AngII-stimulated reactive oxygen species production compared with control mice

• aged tamoxifen-treated mice exhibit attenuated reactive oxygen species production prior to and after AngII-stimulation compared with control mice

muscle

abnormal vasoconstriction ( J:193438 )

• aged tamoxifen-treated mice fail to exhibit an increase in contraction response to KCL or U46619 (thromboxane receptor agonist) unlike control mice

• however, the age-dependent increase in contraction response to phenylephrine is preserved

decreased vasoconstriction ( J:193438 )

• in tamoxifen-treated mice in response to phenylephrine

• in adult tamoxifen-treated mice in response to acetylcholine

• in aged tamoxifen-treated mice in response to BayK8644 (L-type calcium channel agonist)

• in adult and aged tamoxifen-treated mice in response to Ang II

increased vasoconstriction ( J:193438 )

• in aged tamoxifen-treated mice in response to sodium nitroprusside

abnormal vasodilation ( J:193438 )

• aged tamoxifen-treated mice exhibit a modest decrease in endothelial cell-independent vasodilation compared with control mice

increased vasodilation ( J:193438 )

• endothelial-dependent tamoxifen-treated mice

abnormal muscle tone ( J:193438 )

• aged tamoxifen-treated mice develop less spontaneous myogenic tone compared with control mice