Phenotypes associated with this allele

• Allele Symbol: Dclk1^{tm1.1(cre/ERT2)Seno}
• Allele Name: targeted mutation 1.1, Hiroshi Seno
• Allele ID: MGI:5475100
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclk1^tm1.1(cre/ERT2)Seno/Dclk1^tm1.1(cre/ERT2)Seno	C57BL/6-Dclk1^tm1.1(cre/ERT2)Seno	MGI:5475204
cn2	Apc^Min/Apc^+ Dclk1^tm1.1(cre/ERT2)Seno/Dclk1^+ Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1(HBEGF)Awai	involves: 129S4/SvJaeSor * C57BL/6	MGI:5475206
cn3	Ctnnb1^tm1Mmt/Ctnnb1^+ Dclk1^tm1.1(cre/ERT2)Seno/Dclk1^+	involves: 129X1/SvJ * C57BL/6	MGI:5475208
cx4	Apc^Min/Apc^+ Dclk1^tm1.1(cre/ERT2)Seno/Dclk1^tm1.1(cre/ERT2)Seno	involves: C57BL/6	MGI:5475210

Genotype
MGI:5475204

hm1

• Allelic Composition: Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1^{tm1.1(cre/ERT2)Seno}
• Genetic Background: C57BL/6-Dclk1^{tm1.1(cre/ERT2)Seno}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:193873 )

N • animals show no differences in intestinal structure compared to wild-type animals; numbers of crypts and height of villi are not different from controls

Genotype
MGI:5475206

cn2

• Allelic Composition: Apc^Min/Apc⁺; Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

neoplasm

abnormal tumor morphology ( J:193873 )

• after tamoxifen treatment and a single injection of diphtheria toxin (DT), polyps contain many Dclk1-positive apoptotic tumor cells and are severely injured or collapsed with Dclk1-negative polyps not displaying DT-induced apoptosis

digestive/alimentary system

digestive/alimentary phenotype ( J:193873 )

N • after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, these cells are absent from the normal intestine with no significant damage to organ architecture observed in the intestine or stomach

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:193873 )

N • after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, no significant damage in organ architecture is observed in the pancreas or gallbladder

Genotype
MGI:5475208

cn3

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

neoplasm

neoplasm ( J:193873 )

N • 40 days after tamoxifen treatment, mice show no detectable polyp development in the small intestine

Genotype
MGI:5475210

cx4

• Allelic Composition: Apc^Min/Apc⁺; Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1^{tm1.1(cre/ERT2)Seno}
• Genetic Background: involves: C57BL/6

digestive/alimentary system

intestine polyps ( J:193873 )

• Dclk1 mutant homozygotes develop polyps in similar numbers and with similar size distribution as Dclk1 wild-type, Apc^Min/+ controls