All Phenotypes Gpr161<tm1Lex> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr161^tm1Lex/Gpr161^tm1Lex	involves: 129S/SvEv * C57BL/6N	MGI:5475127
cx2	Gpr161^tm1Lex/Gpr161^tm1Lex Kif3a^tm1Gsn/Kif3a^tm1Gsn	involves: 129 * C57BL/6N	MGI:5475130
cx3	Gpr161^tm1Lex/Gpr161^tm1Lex Smo^tm1Amc/Smo^tm1Amc	involves: 129S/SvEv * 129X1/SvJ * C57BL/6N	MGI:5475128

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:193395 )

• at E10.5

craniofacial

abnormal craniofacial morphology ( J:193395 )

• extensive craniofacial abnormalities at E10.5

• abnormalities are detected as early as the 8-10 somite stage

limbs/digits/tail

abnormal limb development ( J:193395 )

• no sign of limb morphogenesis by E10

absent apical ectodermal ridge ( J:193395 )

• at E10

embryo

embryo phenotype ( J:193395 )

N	• at E10 morphology of primary cilia is similar to wild-type controls

abnormal dorsal-ventral axis patterning ( J:193395 )

• defects in dorsal ventral patterning are detected as early as the 8-10 somite stage

absent apical ectodermal ridge ( J:193395 )

• at E10

abnormal neural tube morphology ( J:193395 )

• expression analysis indicates the neural tube is ventralized throughout the spinal cord and hindbrain regions

enlarged floor plate ( J:193395 )

• expansion of the floor plate progenitor domain

spina bifida ( J:193395 )

• spinal cord is open in the most caudal regions

nervous system

abnormal neural tube morphology ( J:193395 )

• expression analysis indicates the neural tube is ventralized throughout the spinal cord and hindbrain regions

enlarged floor plate ( J:193395 )

• expansion of the floor plate progenitor domain

spina bifida ( J:193395 )

• spinal cord is open in the most caudal regions

exencephaly ( J:193395 )

• open forebrain/midbrain regions at E9.5

Allelic Composition	Gpr161^tm1Lex/Gpr161^tm1Lex Kif3a^tm1Gsn/Kif3a^tm1Gsn
Genetic Background	involves: 129 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^tm1Lex mutation (1 available); any Gpr161 mutation (30 available)
Kif3a^tm1Gsn mutation (1 available); any Kif3a mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:193395 )

• general morphology resembles that of Kif3a single mutants

decreased embryo size ( J:193395 )

• similar to Kif3a single mutants

nervous system

abnormal nervous system development ( J:193395 )

• neural patterning resembles that of Kif3a single mutants

growth/size/body

decreased embryo size ( J:193395 )

• similar to Kif3a single mutants

Allelic Composition	Gpr161^tm1Lex/Gpr161^tm1Lex Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr161^tm1Lex mutation (1 available); any Gpr161 mutation (30 available)
Smo^tm1Amc mutation (1 available); any Smo mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:193395 )

• similar to Gpr161 single mutants

embryo

abnormal neural tube morphology ( J:193395 )

• neural tube is ventralized similar to Gpr161 single mutants

growth/size/body

growth/size/body region phenotype ( J:193395 )

N	• unlike in Smo single mutants, growth retardation is not seen at E9.5

nervous system

abnormal neural tube morphology ( J:193395 )

• neural tube is ventralized similar to Gpr161 single mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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