All Phenotypes Chat<tm2(cre)Lowl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chat^tm2(cre)Lowl
targeted mutation 2, Bradford B Lowell
MGI:5475195

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chat^tm2(cre)Lowl/Chat⁺ Mapt^tm2(FUS)Neas/Mapt⁺	B6.129-Mapt^tm2(FUS)Neas Chat^tm2(cre)Lowl	MGI:5823845
cn2	Chat^tm2(cre)Lowl/Chat⁺ Mapt^tm3(FUS)Neas/Mapt⁺	B6.129-Mapt^tm3(FUS)Neas Chat^tm2(cre)Lowl	MGI:5823858
cn3	Chat^tm2(cre)Lowl/Chat⁺ Mapt^{tm3(Sema3e)Arbr}/Mapt^{tm3(Sema3e)Arbr}	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3848833
cn4	Chat^tm2(cre)Lowl/Chat⁺ Mecp2^tm2Bird/Y	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:6098759
cn5	Chat^tm2(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr	MGI:5562538
cn6	Mecp2^tm1Jae/Y Chat^tm2(cre)Lowl/Chat⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:6098756
cn7	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Chat^tm2(cre)Lowl/Chat⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	MGI:4359069
cn8	Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi} Chat^tm2(cre)Lowl/Chat⁺	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N	MGI:5823868
cn9	Chat^tm2(cre)Lowl/Chat⁺ Stmn2^em2Jmi/Stmn2^em2Jmi	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N	MGI:7523313
cn10	Chat^tm2(cre)Lowl/Chat⁺ Plxna2^{tm1a(EUCOMM)Wtsi}/Plxna2^tm1Hfu	involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj	MGI:5562536
cn11	Chat^tm2(cre)Lowl/Chat⁺ Cpeb2^tm1.1Yshu/Cpeb2^tm1.1Yshu	involves: C57BL/6 * C57BL/6J * C57BL/6NJ * SJL/J	MGI:5882505

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Mapt^tm2(FUS)Neas/Mapt⁺
Genetic Background	B6.129-Mapt^tm2(FUS)Neas Chat^tm2(cre)Lowl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mapt^tm2(FUS)Neas mutation (0 available); any Mapt mutation (430 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

motor neuron degeneration ( J:232167 )

• motor neuron loss is seen at P60 but not P30, when 10% of lumbar level 5 (L5) motor neurons are lost and by P360, there are 18.6% fewer motor neurons overall in the L5 segment

abnormal neuromuscular synapse morphology ( J:232167 )

• about 10% denervation of the tibialis anterior neuromuscular junctions (NMJs), first seen at P60 which progresses with age such that at P360, about 25% of NMJs are denervated

• denervation is first noted at P120 in the gastrocnemius muscle where about 10% of NMJs are denervated

• however, even at P360, no denervation is seen in the soleus muscle NMJs

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Mapt^tm3(FUS)Neas/Mapt⁺
Genetic Background	B6.129-Mapt^tm3(FUS)Neas Chat^tm2(cre)Lowl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mapt^tm3(FUS)Neas mutation (0 available); any Mapt mutation (430 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

motor neuron degeneration ( J:232167 )

• significant motor neuron loss is seen at P30 but not P10, and by P360, there are 22.6% fewer motor neurons overall in the lumbar level 5 (L5) segment

abnormal neuromuscular synapse morphology ( J:232167 )

• about 10% denervation of the tibialis anterior neuromuscular junctions, first seen at P20 which progresses with age such that at P360, about 30% of NMJs are denervated

• denervation is first noted at P120 in the gastrocnemius muscle where about 13% of NMJs are denervated

• however, even at P360, no denervation is seen in the soleus muscle NMJs

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Mapt^{tm3(Sema3e)Arbr}/Mapt^{tm3(Sema3e)Arbr}
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mapt^{tm3(Sema3e)Arbr} mutation (0 available); any Mapt mutation (430 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:149553 )

• 23% of triceps motor neurons receive monosynaptic input from triceps afferents compared to 95% in wild-type mice

• however, triceps and cutaneous maximus motor neurons normally lack monosynaptic input from cutaneous maximus afferents

behavior/neurological

behavior/neurological phenotype ( J:149553 )

N	• mice exhibit no behavior deficits

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Mecp2^tm2Bird/Y
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mecp2^tm2Bird mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiration ( J:241788 )

• abnormal hypoxic breathing response

apnea ( J:241788 )

behavior/neurological

behavior/neurological phenotype ( J:241788 )

N	• mice exhibit normal activity

cardiovascular system

cardiovascular system phenotype ( J:241788 )

N	• mice exhibit a regular heart rate and show rescue of spontaneous and induced cardiac arrhythmias, long QT, and improved survival

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:241788 )

N	• mice exhibit a regular body temperature

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze} mutation (4 available); any Gt(ROSA)26Sor mutation (993 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:202884 )

• starburst amacrine cells in flat mount retinas show excess and aberrant light-evoked inhibitory postsynaptic currents

Allelic Composition	Mecp2^tm1Jae/Y Chat^tm2(cre)Lowl/Chat⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Mecp2^tm1Jae mutation (2 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:241788 )

• 67% of mice die early with a median life span of 16 months

cardiovascular system

abnormal heartbeat ( J:241788 )

• irregular heart rhythm and sudden drops in heart rate

increased heart rate variability ( J:241788 )

• increase in heart rate variability during both the light and dark cycles

decreased heart rate ( J:241788 )

• heart rate during the dark cycle is decreased but is not different during the light cycle

ventricular tachycardia ( J:241788 )

• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia

ventricular premature beat ( J:241788 )

• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia

prolonged QT interval ( J:241788 )

increased response of heart to induced stress ( J:241788 )

• mice are highly susceptible to inducible arrhythmias

homeostasis/metabolism

increased response of heart to induced stress ( J:241788 )

• mice are highly susceptible to inducible arrhythmias

decreased body temperature ( J:241788 )

• mice exhibit decreased temperature during the dark cycle but not the light cycle

behavior/neurological

behavior/neurological phenotype ( J:241788 )

N	• mice show no differences in activity during the light or dark cycle

respiratory system

respiratory system phenotype ( J:241788 )

N	• mice do not exhibit increased basal apneas or abnormal hypoxic response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:241788

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Chat^tm2(cre)Lowl/Chat⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (32 available)
App^tm1.1Zhe mutation (1 available); any App mutation (105 available)
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:152457 )

• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2^tm1Dbo App^tm1.2Zhe double homozygotes

Allelic Composition	Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi} Chat^tm2(cre)Lowl/Chat⁺
Genetic Background	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N
Cell Lines	EPD0667_5_C04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Fus^{tm1a(EUCOMM)Wtsi} mutation (0 available); any Fus mutation (48 available)
Fus^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Fus mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:232167 )

N	• no motor neuron degeneration is seen up to 1 year of age

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Stmn2^em2Jmi/Stmn2^em2Jmi
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Stmn2^em2Jmi mutation (0 available); any Stmn2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:337175 )

• 16.8% of mice are obtained at P21, indicating a significant deviation from Mendelian ratios

behavior/neurological

decreased grip strength ( J:337175 )

• at 3 months of age, mice show a significant decrease in the latency time (s) to fall from an inverted screen relative to control mice

nervous system

abnormal neuron morphology ( J:337175 )

• mice develop a distal motor neuropathy

abnormal neuromuscular synapse morphology ( J:337175 )

• at 3 months of age, lumbrical muscles show a NMJ phenotype similar to that of single constitutive Stmn2^em1Jmi homozygotes, where most lumbrical muscle fibers are partially denervated with highly fragmented postsynaptic endplates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
motor peripheral neuropathy		DOID:2477		J:337175

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Plxna2^{tm1a(EUCOMM)Wtsi}/Plxna2^tm1Hfu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Plxna2^{tm1a(EUCOMM)Wtsi} mutation (3 available); any Plxna2 mutation (130 available)
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

abnormal dendrite morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• disruption of the dendritic plexus organization of On but not Off SACs

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Cpeb2^tm1.1Yshu/Cpeb2^tm1.1Yshu
Genetic Background	involves: C57BL/6 * C57BL/6J * C57BL/6NJ * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Cpeb2^tm1.1Yshu mutation (0 available); any Cpeb2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal whole-body plethysmography ( J:237513 )

• whole-body plethysmography revealed respiratory defects similar to those observed in Cpeb2^tm1.2Yshu homozygotes but with wide individual variation in severity

• however, tidal volume is normal at P1

abnormal breathing pattern ( J:237513 )

• aberrant respiration patterns at P1

decreased pulmonary respiratory rate ( J:237513 )

• reduced respiratory frequency at P1

apnea ( J:237513 )

• increased apneic episodes at P1

• inhalation of nebulized tiotropium, an anticholinergic bronchodilator, reduces apnea frequency to wild-type levels

increased airway responsiveness ( J:237513 )

• significantly increased methacholine-induced airway reactivity in adult mice

homeostasis/metabolism

increased acetylcholine level ( J:237513 )

• increased pulmonary acetylcholine level at P1

increased brain choline acetyltransferase activity ( J:237513 )

• increased choline acetyltransferase (ChAT) expression in the dorsal motor nucleus of vagus (DMNV)

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