Phenotypes associated with this allele

• Allele Symbol: Gclc^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5475270
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gclc^tm1c(EUCOMM)Wtsi/Gclc^tm1c(EUCOMM)Wtsi Tg(Cryaa-cre)10Mlr/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:5475286
cn2	Gclc^tm1c(EUCOMM)Wtsi/Gclc^+ Tg(Cryaa-cre)10Mlr/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:5475288

Genotype
MGI:5475286

cn1

• Allelic Composition: Gclc^{tm1c(EUCOMM)Wtsi}/Gclc^{tm1c(EUCOMM)Wtsi}; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0051_3_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cataracts in Gclc^{tm1c(EUCOMM)Wtsi}/Gclc^{tm1c(EUCOMM)Wtsi} Tg(Cryaa-cre)10Mlr/0 mice

vision/eye

cataract ( J:194778 )

• in some mice starting at 3 months

• mature cataracts in half of mice by 4 months

nuclear cataract ( J:194778 )

• small at 4 months

• severe at 9 months

cellular

oxidative stress ( J:194778 )

• strong increase in reactive oxygen species production as determined by GSSG/GSH ratio

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:194778

Genotype
MGI:5475288

cn2

• Allelic Composition: Gclc^{tm1c(EUCOMM)Wtsi}/Gclc⁺; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0051_3_D07

cellular

oxidative stress ( J:194778 )

• mild increase in reactive oxygen species production as determined by GSSG/GSH ratio