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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl11atm2.1Peli
targeted mutation 2.1, Pentao Liu
MGI:5475336
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl11atm2.1Peli/Bcl11atm2.1Peli
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:5475382
cn2
 		Bcl11atm2.1Peli/Bcl11atm2.1Peli
Trp53tm1Brn/Trp53tm1Brn
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:5475383


Genotype
MGI:5475382
cn1
Allelic
Composition		 Bcl11atm2.1Peli/Bcl11atm2.1Peli
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm2.1Peli mutation (0 available); any Bcl11a mutation (44 available)
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell apoptosis ( J:194616 )
• in pro-B, pre-B and immature B cells of tamoxifen-treated mice
• however, apoptosis is rescued by exogenous Bcl2 or Mdm2 and Bcl2
decreased pro-B cell number ( J:194616 )
• in the bone marrow of tamoxifen-treated mice
abnormal T cell differentiation ( J:194616 )
• few early T cell progenitors in the thymus of tamoxifen-treated mice
decreased DN2 thymocyte number ( J:194616 )
• in tamoxifen-treated mice
abnormal common lymphocyte progenitor cell morphology ( J:194616 )
• reduced 7-fold in tamoxifen-treated mice
decreased B cell number ( J:194616 )
• in the bone marrow of tamoxifen-treated mice
• however, the number of B cells in the spleen, lymph node and peripheral blood is normal
decreased immature B cell number ( J:194616 )
• to one-fifth of wild-type levels in the bone marrow of tamoxifen-treated mice
decreased pre-B cell number ( J:194616 )
• in the bone marrow of tamoxifen-treated mice
decreased hematopoietic stem cell number ( J:194616 )
• reduced LSK and lymphoid-primed multipotent progenitors in tamoxifen-treated mice
abnormal hematopoietic stem cell physiology ( J:194616 )
• tamoxifen-treated LSK cells exhibit a complete loss of lymphoid development

cellular
increased B cell apoptosis ( J:194616 )
• in pro-B, pre-B and immature B cells of tamoxifen-treated mice
• however, apoptosis is rescued by exogenous Bcl2 or Mdm2 and Bcl2

immune system
increased B cell apoptosis ( J:194616 )
• in pro-B, pre-B and immature B cells of tamoxifen-treated mice
• however, apoptosis is rescued by exogenous Bcl2 or Mdm2 and Bcl2
abnormal immune system morphology ( J:194616 )
• complete loss of lymphoid development in tamoxifen-treated bone marrow cells is cell autonomous
decreased pro-B cell number ( J:194616 )
• in the bone marrow of tamoxifen-treated mice
abnormal T cell differentiation ( J:194616 )
• few early T cell progenitors in the thymus of tamoxifen-treated mice
decreased DN2 thymocyte number ( J:194616 )
• in tamoxifen-treated mice
decreased B cell number ( J:194616 )
• in the bone marrow of tamoxifen-treated mice
• however, the number of B cells in the spleen, lymph node and peripheral blood is normal
decreased immature B cell number ( J:194616 )
• to one-fifth of wild-type levels in the bone marrow of tamoxifen-treated mice
decreased pre-B cell number ( J:194616 )
• in the bone marrow of tamoxifen-treated mice

endocrine/exocrine glands
decreased DN2 thymocyte number ( J:194616 )
• in tamoxifen-treated mice




Genotype
MGI:5475383
cn2
Allelic
Composition		 Bcl11atm2.1Peli/Bcl11atm2.1Peli
Trp53tm1Brn/Trp53tm1Brn
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm2.1Peli mutation (0 available); any Bcl11a mutation (44 available)
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:194616 )
N
• early B cell development is rescued in tamoxifen treated mice
decreased hematopoietic stem cell number ( J:194616 )
• reduced LSK and lymphoid-primed multipotent progenitors in tamoxifen-treated mice
abnormal hematopoietic stem cell physiology ( J:194616 )
• tamoxifen-treated LSK cells exhibit a complete loss of lymphoid development

immune system
immune system phenotype ( J:194616 )
N
• early B cell development is rescued in tamoxifen treated mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory