Phenotypes associated with this allele

• Allele Symbol: Cdkl5^tm1.1Joez
• Allele Name: targeted mutation 1.1, Zhaolan Zhou
• Allele ID: MGI:5475468
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Cdkl5^tm1.1Joez/Y	B6.129(FVB)-Cdkl5^tm1.1Joez	MGI:5475523

Genotype
MGI:5475523

ot1

• Allelic Composition: Cdkl5^tm1.1Joez/Y
• Genetic Background: B6.129(FVB)-Cdkl5^tm1.1Joez

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hindlimb clasping in Cdkl5^tm1.1Joez/Y mice

behavior/neurological

impaired contextual conditioning behavior ( J:193172 )

♂

impaired cued conditioning behavior ( J:193172 )

♂

decreased anxiety-related response ( J:193172 )

♂ • in a zero maze test

limb grasping ( J:193172 )

♂ • fore and hind limb

impaired coordination ( J:193172 )

♂

hyperactivity ( J:193172 )

♂

abnormal nest building behavior ( J:193172 )

♂ • impaired nesting

social withdrawal ( J:193172 )

♂ • impaired social interaction

nervous system

nervous system phenotype ( J:193172 )

♂N • mice exhibit normal EEG patterns and no spontaneous seizures

abnormal nervous system electrophysiology ( J:193172 )

♂ • mice exhibit deficits in auditory-evoked event-related potentials with aberrant waveform compared with wild-type mice

♂ • mice exhibit disruptions in low-frequency event-related neuronal oscillations compared with wild-type mice

taste/olfaction

taste/olfaction phenotype ( J:193172 )

♂N • mice exhibit normal olfaction