Phenotypes associated with this allele

• Allele Symbol: Il7r^tm2Iku
• Allele Name: targeted mutation 2, Koichi Ikuta
• Allele ID: MGI:5475476
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il7r^tm2Iku/Il7r^tm2Iku Tg(Cd4-cre)1Cwi/? Tg(H2-K-BCL2)1Josd/?	involves: 129S6/SvEvTac * C57BL/6 * C3H * DBA/2	MGI:5475545
cn2	Il7r^tm2Iku/Il7r^tm2Iku Tg(Cd4-cre)1Cwi/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5475544

Genotype
MGI:5475545

cn1

• Allelic Composition: Il7r^tm2Iku/Il7r^tm2Iku; Tg(Cd4-cre)1Cwi/?; Tg(H2-K-BCL2)1Josd/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C3H * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:193283 )

N • CD8+ numbers and CD8+/CD4+ ratio recovered from condition in mice lacking Tg(H2-K-BCL2)1Josd

Genotype
MGI:5475544

cn2

• Allelic Composition: Il7r^tm2Iku/Il7r^tm2Iku; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

immune system

increased B cell number ( J:193283 )

• increased B cell lineages

abnormal T cell morphology ( J:193283 )

increased thymocyte number ( J:193283 )

• slightly

• number of double negative thymocytes is doubled

abnormal CD4-positive T cell differentiation ( J:193283 )

• generation of mature CD4+ cells is impaired

• 2-3 fold reduction of proliferation in the thymus

abnormal CD8-positive, alpha-beta T cell differentiation ( J:193283 )

• generation of mature CD4+ cells is impaired

• 2-3 fold reduction of proliferation in the thymus

decreased NK T cell number ( J:193283 )

• reduced frequency of stage 3 invariant NKT cells

• double negative invariant NKT cells are reduced

increased gamma-delta T cell number ( J:193283 )

• increased in the thymus by 1.5 fold

hematopoietic system

increased B cell number ( J:193283 )

• increased B cell lineages

abnormal T cell morphology ( J:193283 )

increased thymocyte number ( J:193283 )

• slightly

• number of double negative thymocytes is doubled

abnormal CD4-positive T cell differentiation ( J:193283 )

• generation of mature CD4+ cells is impaired

• 2-3 fold reduction of proliferation in the thymus

abnormal CD8-positive, alpha-beta T cell differentiation ( J:193283 )

• generation of mature CD4+ cells is impaired

• 2-3 fold reduction of proliferation in the thymus

decreased NK T cell number ( J:193283 )

• reduced frequency of stage 3 invariant NKT cells

• double negative invariant NKT cells are reduced

increased gamma-delta T cell number ( J:193283 )

• increased in the thymus by 1.5 fold

endocrine/exocrine glands

increased thymocyte number ( J:193283 )

• slightly

• number of double negative thymocytes is doubled