All Phenotypes Mlana<tm1.2Bee> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mlana^tm1.2Bee
targeted mutation 1.2, Friedrich Beermann
MGI:5476663

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlana^tm1.2Bee/Mlana^tm1.2Bee	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL	MGI:5484926
cx2	Mlana^tm1.2Bee/Mlana^tm1.2Bee Tyr^c/Tyr^c	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL	MGI:5484927

Allelic Composition	Mlana^tm1.2Bee/Mlana^tm1.2Bee
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlana^tm1.2Bee mutation (1 available); any Mlana mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:194886 )

N	• mice exhibit normal tail skin, footpad and retina pigmentation

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice

• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice

diluted coat color ( J:194886 )

• visible 5 days after birth

integument

abnormal coat/ hair morphology ( J:194886 )

• reduced number of hairs

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice

• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice

diluted coat color ( J:194886 )

• visible 5 days after birth

Allelic Composition	Mlana^tm1.2Bee/Mlana^tm1.2Bee Tyr^c/Tyr^c
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlana^tm1.2Bee mutation (1 available); any Mlana mutation (9 available)
Tyr^c mutation (80 available); any Tyr mutation (379 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicles lack stage III and IV melanosomes

• however, stage I and II melanosomes are normal

absent skin pigmentation ( J:194886 )

integument

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicles lack stage III and IV melanosomes

• however, stage I and II melanosomes are normal

absent skin pigmentation ( J:194886 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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