All Phenotypes Mlana<tm1.2Bee> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mlana^tm1.2Bee
targeted mutation 1.2, Friedrich Beermann
MGI:5476663

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlana^tm1.2Bee/Mlana^tm1.2Bee	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL	MGI:5484926
cx2	Mlana^tm1.2Bee/Mlana^tm1.2Bee Tyr^c/Tyr^c	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL	MGI:5484927

Allelic Composition	Mlana^tm1.2Bee/Mlana^tm1.2Bee
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlana^tm1.2Bee mutation (1 available); any Mlana mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:194886 )

N	• mice exhibit normal tail skin, footpad and retina pigmentation

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice

• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice

diluted coat color ( J:194886 )

• visible 5 days after birth

integument

abnormal coat/ hair morphology ( J:194886 )

• reduced number of hairs

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicle melanosomes have reduced melanin and eumelanin content compared with melanosomes from wild-type mice

• melanosomes in hair follicles exhibit blebbing of the limiting membrane with vesicles between the pigmented compartment and the limiting membrane unlike melanosomes from wild-type mice

diluted coat color ( J:194886 )

• visible 5 days after birth

Allelic Composition	Mlana^tm1.2Bee/Mlana^tm1.2Bee Tyr^c/Tyr^c
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlana^tm1.2Bee mutation (1 available); any Mlana mutation (9 available)
Tyr^c mutation (80 available); any Tyr mutation (379 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicles lack stage III and IV melanosomes

• however, stage I and II melanosomes are normal

absent skin pigmentation ( J:194886 )

integument

abnormal hair follicle melanocyte morphology ( J:194886 )

• hair follicles lack stage III and IV melanosomes

• however, stage I and II melanosomes are normal

absent skin pigmentation ( J:194886 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24