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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Yjc
targeted mutation 1, Y Jeffrey Chiang
MGI:5476675
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1Yjc/Trp53tm1Yjc B6.129S1-Trp53tm1Yjc MGI:5476679
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Trp53tm1Yjc/Trp53tm1Yjc 		involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6 MGI:5476680


Genotype
MGI:5476679
hm1
Allelic
Composition		 Trp53tm1Yjc/Trp53tm1Yjc
Genetic
Background		 B6.129S1-Trp53tm1Yjc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Yjc mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Trp53tm1Yjc/Trp53tm1Yjc mice develop B cell lymphomas

mortality/aging
premature death ( J:195018 )
• all mice die by 48 weeks of age due to lymphoma development

immune system
immune system phenotype ( J:195018 )
N
• radiation-induced apoptosis in thymocytes is normal
decreased splenocyte apoptosis ( J:195018 )
• in irradiated spleen cells
enlarged spleen ( J:195018 )
• in 23 of 29 mice at death
abnormal spleen white pulp morphology ( J:195018 )
• compression of white pulp in some mice
abnormal spleen marginal zone morphology ( J:195018 )
• marginal zone invasion of red pulp

neoplasm
increased splenic marginal zone lymphoma incidence ( J:195018 )
• with marginal zone invasion of red pulp
increased sarcoma incidence ( J:195018 )
• in two mice at death

liver/biliary system
enlarged liver ( J:195018 )
• in one mouse at death

integument
skin lesions ( J:195018 )
• in two mice at death

cellular
decreased splenocyte apoptosis ( J:195018 )
• in irradiated spleen cells

hematopoietic system
decreased splenocyte apoptosis ( J:195018 )
• in irradiated spleen cells
enlarged spleen ( J:195018 )
• in 23 of 29 mice at death
abnormal spleen white pulp morphology ( J:195018 )
• compression of white pulp in some mice
abnormal spleen marginal zone morphology ( J:195018 )
• marginal zone invasion of red pulp

growth/size/body
enlarged liver ( J:195018 )
• in one mouse at death
enlarged spleen ( J:195018 )
• in 23 of 29 mice at death




Genotype
MGI:5476680
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Trp53tm1Yjc/Trp53tm1Yjc
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Trp53tm1Yjc mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:195018 )
N
• mice do not develop B cell lymphomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory