Phenotypes associated with this allele

• Allele Symbol: Camk2d^tm1.1Jhb
• Allele Name: targeted mutation 1.1, Joan Heller Brown
• Allele ID: MGI:5476688
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb	involves: 129S4/SvJae * Black Swiss	MGI:5476689
hm2	Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb	Not Specified	MGI:5571876

Genotype
MGI:5476689

hm1

• Allelic Composition: Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb
• Genetic Background: involves: 129S4/SvJae * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb hearts show a decreased response to induced stress

cardiovascular system

decreased response of heart to induced stress ( J:149675 )

• mice fail to develop heart failure induced by long-term transverse aortic constriction and exhibit improved survival and decreased cardiomyocytes apoptosis, fibrosis, calcium ion leak, heart weight and lung edema compared with wild-type mice

• however, mice exhibit normal cardiac hypertrophy induced by 2 week transverse aortic constriction

homeostasis/metabolism

decreased response of heart to induced stress ( J:149675 )

• mice fail to develop heart failure induced by long-term transverse aortic constriction and exhibit improved survival and decreased cardiomyocytes apoptosis, fibrosis, calcium ion leak, heart weight and lung edema compared with wild-type mice

• however, mice exhibit normal cardiac hypertrophy induced by 2 week transverse aortic constriction

Genotype
MGI:5571876

hm2

• Allelic Composition: Camk2d^tm1.1Jhb/Camk2d^tm1.1Jhb
• Genetic Background: Not Specified

muscle

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency and decrease in calcium transient amplitudes are abolished