About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rgs4tm1.1Amus
targeted mutation 1.1, Anthony J Muslin
MGI:5476691
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rgs4tm1.1Amus/Rgs4tm1.1Amus B6.129-Rgs4tm1.1Amus MGI:5476694


Genotype
MGI:5476694
hm1
Allelic
Composition		 Rgs4tm1.1Amus/Rgs4tm1.1Amus
Genetic
Background		 B6.129-Rgs4tm1.1Amus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs4tm1.1Amus mutation (0 available); any Rgs4 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:195186 )
• means survival of mice treated with cyclosporine A is 9 days compared with 25 days for wild-type mice

renal/urinary system
decreased renal plasma flow rate ( J:195186 )
• in mice treated with cyclosporine A, specifically in the medulla and cortex
• however, treatment with bosentan restores renal plasma flow rate

cardiovascular system
decreased renal plasma flow rate ( J:195186 )
• in mice treated with cyclosporine A, specifically in the medulla and cortex
• however, treatment with bosentan restores renal plasma flow rate

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:195186 )
• means survival of mice treated with cyclosporine A is 9 days compared with 25 days for wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory