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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k8tm1.1Gkl
targeted mutation 1.1, George Kollias
MGI:5476710
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Tg(Col6a1-cre)1Gkl/0 		involves: C57BL/6 * CBA * FVB/N MGI:5476715
cn2
 		Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: C57BL/6 * FVB/N MGI:5476713
cn3
 		Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6 * FVB/N * SJL MGI:5476714


Genotype
MGI:5476715
cn1
Allelic
Composition		 Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Tg(Col6a1-cre)1Gkl/0
Genetic
Background		 involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1.1Gkl mutation (1 available); any Map3k8 mutation (41 available)
Tg(Col6a1-cre)1Gkl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased enterocyte apoptosis ( J:193546 )
• decreased in mice treated with AOM/DSS
abnormal enterocyte proliferation ( J:193546 )
• increased in mice treated with AOM/DSS
abnormal colon morphology ( J:193546 )
• high-grade dysplasia in mice treated with AOM/DSS

neoplasm
increased incidence of tumors by chemical induction ( J:193546 )
• higher tumor burdens and tumor size in mice treated with AOM/DSS
increased tumor growth/size ( J:193546 )
• higher tumor burdens and tumor size in mice treated with AOM/DSS

cellular
decreased enterocyte apoptosis ( J:193546 )
• decreased in mice treated with AOM/DSS
abnormal enterocyte proliferation ( J:193546 )
• increased in mice treated with AOM/DSS

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:193546 )
N
• mice treated with AOM/DSS exhibit normal body weight loss, decreased colon length, inflammation and tissue damage
increased incidence of tumors by chemical induction ( J:193546 )
• higher tumor burdens and tumor size in mice treated with AOM/DSS




Genotype
MGI:5476713
cn2
Allelic
Composition		 Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Map3k8tm1.1Gkl mutation (1 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:193546 )
N
• mice treated with AOM/DSS exhibit normal body weight loss, decreased colon length, inflammation and tissue damage

neoplasm
neoplasm ( J:193546 )
N
• mice treated with AOM/DSS exhibit normal tumor formation




Genotype
MGI:5476714
cn3
Allelic
Composition		 Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1.1Gkl mutation (1 available); any Map3k8 mutation (41 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:193546 )
N
• mice treated with AOM/DSS exhibit normal body weight loss, decreased colon length, inflammation and tissue damage

neoplasm
neoplasm ( J:193546 )
N
• mice treated with AOM/DSS exhibit normal tumor formation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory