Phenotypes associated with this allele

• Allele Symbol: Il36rn^tm1Kopf
• Allele Name: targeted mutation 1, Manfred Kopf
• Allele ID: MGI:5476725
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il36rn^tm1Kopf/Il36rn^tm1Kopf	B6.129S5-Il36rn^tm1Kopf	MGI:5476731

Genotype
MGI:5476731

hm1

• Allelic Composition: Il36rn^tm1Kopf/Il36rn^tm1Kopf
• Genetic Background: B6.129S5-Il36rn^tm1Kopf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Il1rl2^tm1Hblu/Il1rl2^tm1Hblu and Il36rn^tm1Kopf/Il36rn^tm1Kopf mice show different susceptibilities to IMQ-induced psoriasiform dermatitis

integument

dermatitis ( J:193548 )

• IMQ-treated mice develop psoriasiform dermatitis

hyperkeratosis ( J:193548 )

• in IMQ-treated mice

acanthosis ( J:193548 )

• in IMQ-treated mice

flaky skin ( J:193548 )

• in IMQ-treated mice

reddish skin ( J:193548 )

• in IMQ-treated mice

psoriasis ( J:193548 )

• IMQ-treated mice develop psoriasiform dermatitis

immune system

increased leukocyte cell number ( J:193548 )

• IMQ-treated mice exhibit a 3-fold increase in CD45+ leukocyte infiltration in the skin compared with wild-type mice

increased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

dermatitis ( J:193548 )

• IMQ-treated mice develop psoriasiform dermatitis

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:193548 )

• mice treated with IMQ (Aldara) exhibit increased ear swelling, acanthosis, erythema, skin flaking and hyperkeratosis compared with wild-type mice

hematopoietic system

increased leukocyte cell number ( J:193548 )

• IMQ-treated mice exhibit a 3-fold increase in CD45+ leukocyte infiltration in the skin compared with wild-type mice

increased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice