Analysis Tools
immune system
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• the increase in the percentage and total number of IL13+ST2+ type 2 cytokine producing innate lymphoid cells in the lung at 3 days after hookworm infection are reduced compared to controls
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• type 2 cytokine producing innate lymphoid cells fail to produce IL13 at 6 days after hookworm infection
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• at 6 days after infection with N. brasiliensis mice have 3 fold greater intestinal worm numbers and mice fail to increase IL13 at 3 and 6 days postinfection
• mice remain chronically infected at greater than 21 days following infection unlike wild-type controls that clear parasites by 10 days post infection
• a threefold increase is seen in red blood cell numbers in bronchoalveolar lavage fluid at 3 days after infection compared to infected wild-type mice
• mice are more susceptible to secondary infection following treatment with the antihelminthic drug pyrantel pamoate with 10 fold higher numbers of worms at 3 days after infection
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hematopoietic system
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• the increase in the percentage and total number of IL13+ST2+ type 2 cytokine producing innate lymphoid cells in the lung at 3 days after hookworm infection are reduced compared to controls
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