Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm2.1Tes
• Allele Name: targeted mutation 2.1, Lino Tessarollo
• Allele ID: MGI:5476922
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm2.1Tes/Ntrk2^tm2.1Tes	involves: 129S4/SvJae * C57BL/6J	MGI:5476925

Genotype
MGI:5476925

hm1

• Allelic Composition: Ntrk2^tm2.1Tes/Ntrk2^tm2.1Tes
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:193542 )

N • mice exhibit normal paired-pulse facilitation

abnormal axon extension ( J:193542 )

• neurons fail to respond to BDNF treatment with increased spine density and area unlike wild-type cells

• however, untreated neurons exhibit normal spine density and size

reduced long-term potentiation ( J:193542 )

• following application of BDNF

behavior/neurological

behavior/neurological phenotype ( J:193542 )

N • mice exhibit normal spatial learning and fear memory

abnormal spatial working memory ( J:193542 )

• impaired hippocampus-dependent memory in a Morris water maze test

abnormal response to novel object ( J:193542 )

• mice fail to exhibit a preference for exploring a novel object

cellular

abnormal axon extension ( J:193542 )

• neurons fail to respond to BDNF treatment with increased spine density and area unlike wild-type cells

• however, untreated neurons exhibit normal spine density and size