All Phenotypes Mutyh<tm1Yun> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mutyh^tm1Yun
targeted mutation 1, Yusaku Nakabeppu
MGI:5476928

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mutyh^tm1Yun/Mutyh^tm1Yun	involves: 129 * C57BL/6JJcl	MGI:5476990
cx2	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun	MGI:5476986
cx3	Mutyh^tm1Yun/Mutyh^tm1Yun Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476987

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun
Genetic Background	involves: 129 * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit increased survival, reduced neurodegeneration, better performance in an open field test and maintained mitochondrial morphology and function compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit increased survival, reduced neurodegeneration, better performance in an open field test and maintained mitochondrial morphology and function compared with wild-type mice

cellular

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit increased survival, reduced neurodegeneration, better performance in an open field test and maintained mitochondrial morphology and function compared with wild-type mice

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (36 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:193978 )

• mice are highly susceptible to spontaneous tumorigenesis within 100 days of birth

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (36 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

cellular

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

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