Phenotypes associated with this allele

• Allele Symbol: Ube2o^{tm1.1(KOMP)Mbp}
• Allele Name: targeted mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:5477804
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2o^tm1.1(KOMP)Mbp/Ube2o^tm1.1(KOMP)Mbp	B6N(Cg)-Ube2o^tm1.1(KOMP)Mbp/J	MGI:5763857
hm2	Ube2o^tm1.1(KOMP)Mbp/Ube2o^tm1.1(KOMP)Mbp	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:5902962
ht3	Ube2o^tm1.1(KOMP)Mbp/Ube2o^+	B6N(Cg)-Ube2o^tm1.1(KOMP)Mbp/J	MGI:5763856
cx4	Ube2o^tm1.1(KOMP)Mbp/Ube2o^tm1.1(KOMP)Mbp Pten^tm1Ppp/Pten^tm1Ppp	involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N	MGI:5902970
cx5	Ube2o^tm1.1(KOMP)Mbp/Ube2o^+ Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:5902964
cx6	Ube2o^tm1.1(KOMP)Mbp/Ube2o^tm1.1(KOMP)Mbp Tg(TRAMP)8247Ng/0	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:5902965
cx7	Ube2o^tm1.1(KOMP)Mbp/Ube2o^+ Tg(TRAMP)8247Ng/0	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:5902966
cx8	Ube2o^tm1.1(KOMP)Mbp/Ube2o^tm1.1(KOMP)Mbp Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:5902963
cx9	Ube2o^tm1.1(KOMP)Mbp/Ube2o^tm1.1(KOMP)Mbp Tg(IghMyc)22Bri/0	involves: C57BL * C57BL/6N * FVB/N * SJL	MGI:5902968

Genotype
MGI:5763857

hm1

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o^{tm1.1(KOMP)Mbp}
• Genetic Background: B6N(Cg)-Ube2o^{tm1.1(KOMP)Mbp}/J
• Cell Lines: DEPD00564_2_D02

Data Sources

IMPC Data for Ube2o

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5902962

hm2

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o^{tm1.1(KOMP)Mbp}
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

cellular

abnormal cell physiology ( J:239679 )

• in foci-forming assays, cells exhibit resistance to cellular oncogenic transformation compared with wild-type cells

abnormal cell migration ( J:239679 )

• in mouse embryonic fibroblasts

decreased fibroblast proliferation ( J:239679 )

• slowed in mouse embryonic fibroblasts

Genotype
MGI:5763856

ht3

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o⁺
• Genetic Background: B6N(Cg)-Ube2o^{tm1.1(KOMP)Mbp}/J
• Cell Lines: DEPD00564_2_D02

Data Sources

IMPC Data for Ube2o

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:5902970

cx4

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o^{tm1.1(KOMP)Mbp}; Pten^tm1Ppp/Pten^tm1Ppp
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N

neoplasm

increased lymphoma incidence ( J:239679 )

• as in Pten^tm1Ppp homozygotes

Genotype
MGI:5902964

cx5

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

mortality/aging

increased tumor-free survival time ( J:239679 )

• mice exhibit extended survival compared with Tg(MMTV-PyVT)634Mul mice

neoplasm

decreased tumor growth/size ( J:239679 )

• reduced tumor size and weight of mammary glands compared with Tg(MMTV-PyVT)634Mul mice

increased tumor latency ( J:239679 )

• compared with Tg(MMTV-PyVT)634Mul mice

Genotype
MGI:5902965

cx6

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o^{tm1.1(KOMP)Mbp}; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

neoplasm

decreased metastatic potential ( J:239679 )

• mice do not exhibit metastasis to the liver and lymph nodes unlike Tg(TRAMP)8247Ng mice

decreased tumor growth/size ( J:239679 )

• reduced tumor volume and weight without evidence of invasive prostatic adenocarcinoma compared with Tg(TRAMP)8247Ng mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:239679 )

N • unlike in Tg(TRAMP)8247Ng mice, prostate histology is normal

Genotype
MGI:5902966

cx7

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o⁺; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

neoplasm

decreased tumor growth/size ( J:239679 )

• reduced tumor volume and weight compared with Tg(TRAMP)8247Ng mice

Genotype
MGI:5902963

cx8

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o^{tm1.1(KOMP)Mbp}; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

mortality/aging

increased tumor-free survival time ( J:239679 )

• mice exhibit extended survival compared with Tg(MMTV-PyVT)634Mul mice

neoplasm

decreased tumor growth/size ( J:239679 )

• reduced tumor size and weight of mammary glands compared with Tg(MMTV-PyVT)634Mul mice

• 7 of 13 mice exhibit no tumors

increased tumor latency ( J:239679 )

• compared with Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

mammary gland hypoplasia ( J:239679 )

• non-malignant

integument

mammary gland hypoplasia ( J:239679 )

• non-malignant

Genotype
MGI:5902968

cx9

• Allelic Composition: Ube2o^{tm1.1(KOMP)Mbp}/Ube2o^{tm1.1(KOMP)Mbp}; Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL * C57BL/6N * FVB/N * SJL

mortality/aging

decreased survivor rate ( J:239679 )

• as in Tg(IghMyc)22Bri mice

neoplasm

increased B cell derived lymphoma incidence ( J:239679 )

• as in Tg(IghMyc)22Bri mice