All Phenotypes Epn1<tm1.1Wami> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:5477818
cn2	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0	involves: 129X1/SvJ * C57BL/6J	MGI:5477817
cn3	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0	involves: C57BL/6J * FVB/N	MGI:5477819

Allelic Composition	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1^tm1.1Wami mutation (0 available); any Epn1 mutation (33 available)
Epn2^tm1Ocr mutation (0 available); any Epn2 mutation (74 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced tumor growth in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0 mice

mortality/aging

increased tumor-free survival time ( J:193966 )

• tamoxifen-treated mice exhibit decreased mortality compared with Tg(TRAMP)8247Ng control mice

neoplasm

decreased tumor growth/size ( J:193966 )

• tamoxifen-treated mice develop smaller tumors compared with Tg(TRAMP)8247Ng control mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Disrupted endothelial junctions in tumor vessels of Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 mice

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:193966 )

• tamoxifen-treated mice transplanted with GL261glioma cells survive longer than with control mice

neoplasm

abnormal tumor vascularization ( J:193966 )

• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice

• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature

decreased incidence of tumors by chemical induction ( J:193966 )

• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

decreased tumor growth/size ( J:193966 )

• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer, smaller tumors that grow at a slower rate compared with control mice

• tamoxifen-treated mice transplanted with GL261glioma cells develop smaller tumors compared with control mice

• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

cardiovascular system

abnormal tumor vascularization ( J:193966 )

• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice

• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature

abnormal vascular endothelial cell migration ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells

abnormal vascular endothelial cell physiology ( J:193966 )

• endothelial cells treated with tamoxifen exhibit disrupted endothelial junctions compared with control cells

increased vascular endothelial cell proliferation ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells

increased vascular permeability ( J:193966 )

• of tumor vasculature in tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells

• however, vascular permeability of blood vessels in major organs is normal

cellular

abnormal vascular endothelial cell migration ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells

increased vascular endothelial cell proliferation ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:193966 )

• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

Allelic Composition	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced tumor growth in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0 mice

neoplasm

decreased tumor growth/size ( J:193966 )

• mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer tumors that grow at a slower rate compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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