All Phenotypes Tg(Myh6-icre/ERT2)#Wet MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Myh6-icre/ERT2)#Wet
transgene insertion, Nina Wettschureck
MGI:5477906

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gja1^tm10Kwi/Gja1^tm10Kwi Tg(Myh6-icre/ERT2)#Wet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5477914
cn2	Gjc1^tm1Kwi/Gjc1^tm1Kwi Tg(Myh6-icre/ERT2)#Wet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5544304
cn3	Gjc1^tm1Kwi/Gjc1^tm1Kwi Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi Tg(Myh6-icre/ERT2)#Wet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5544303

Allelic Composition	Gja1^tm10Kwi/Gja1^tm10Kwi Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1^tm10Kwi mutation (1 available); any Gja1 mutation (60 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194957 )

• all mice die 16 to 21 days after tamoxifen-treatment

cardiovascular system

cardiovascular system phenotype ( J:194957 )

N	• mice exhibit normal heart beating frequency and PQ duration

ventricular tachycardia ( J:194957 )

• sustained polymorphic ventricular tachycardia degenerating into ventricular fibrillation in tamoxifen-treated mice

• tamoxifen-treated mice exhibit sustained ventricular tachycardia or ventricular fibrillation induced by fixed-rate epicardial stimulation of the ventricle unlike control mice

irregular heartbeat ( J:194957 )

• non-sustained episodes of monomorphic and polymorphic ventricular arrhythmias 15 to 17 days after tamoxifen-treatment

ventricular fibrillation ( J:194957 )

• in tamoxifen-treated mice

atrioventricular block ( J:194957 )

• in tamoxifen-treated mice

prolonged QRS complex duration ( J:194957 )

• 2.1-fold in tamoxifen-treated mice

abnormal myocardial fiber physiology ( J:194957 )

• cardiomyocytes form tamoxifen-treated mice exhibit reduced average peak inward sodium current density, prolonged time course of inward sodium channel inactivation, reduced average peak outward current density and increased action potential duration at 50 and 70% depolarization compared with control cells

• however, cardiomyocytes exhibit normal voltage-dependent inactivation, time course of recovery from inactivation, density of inward rectifier current, resting potential, action potential amplitude and action potential duration at 90% repolarization

Allelic Composition	Gjc1^tm1Kwi/Gjc1^tm1Kwi Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1^tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:205110 )

• embryos treated with tamoxifen at E8.5 and E9.5 die beyond E10.5

• however, mice not treated with tamoxifen develop normally

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N	• tamoxifen-treated mice do not exhibit spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval compared with control mice

prolonged PQ interval ( J:205110 )

• in tamoxifen-treated mice

abnormal sinoatrial node conduction ( J:205110 )

• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice

Allelic Composition	Gjc1^tm1Kwi/Gjc1^tm1Kwi Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1^tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjd3^tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205110 )

N	• tamoxifen-treated mice are viable

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N	• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice

prolonged PQ interval ( J:205110 )

• in tamoxifen-treated mice

abnormal sinoatrial node conduction ( J:205110 )

• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice

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