Phenotypes associated with this allele

• Allele Symbol: Tbc1d4^tm1.2Arte
• Allele Name: targeted mutation 1.2, TaconicArtemis
• Allele ID: MGI:5478502
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbc1d4^tm1.2Arte/Tbc1d4^tm1.2Arte	involves: C57BL/6 * CBA	MGI:5478506

Genotype
MGI:5478506

hm1

• Allelic Composition: Tbc1d4^tm1.2Arte/Tbc1d4^tm1.2Arte
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating free fatty acids level ( J:194026 )

• slightly under fasted conditions

decreased energy expenditure ( J:194026 )

• with lowered rates of oxygen consumption and heat production

decreased oxygen consumption ( J:194026 )

abnormal glucose homeostasis ( J:194026 )

• mice are intolerant to pyruvate challenge, indicating increased hepatic gluconeogenesis

decreased circulating glucose level ( J:194026 )

• under fed and fasted conditions

decreased circulating insulin level ( J:194026 )

• slightly under randomly fed conditions but normal under fasted conditions

abnormal gluconeogenesis ( J:194026 )

• mice are intolerant to pyruvate challenge, indicating increased hepatic gluconeogenesis

impaired glucose tolerance ( J:194026 )

insulin resistance ( J:194026 )

decreased adiponectin level ( J:194026 )

• slightly under fasted conditions

• under randomly fed conditions

decreased basal metabolism ( J:194026 )

• reduced heat production

adipose tissue

decreased adipocyte glucose uptake ( J:194026 )

• impaired under insulin-stimulated conditions

increased adipocyte glucose uptake ( J:194026 )

• increased under basal conditions

muscle

decreased skeletal muscle cell glucose uptake ( J:194026 )

• impaired 2-fold in the soleus muscle under basal conditions and blunted under insulin-stimulated conditions

• however, glucose uptake in the extensor digitorum longus is normal

cellular

decreased adipocyte glucose uptake ( J:194026 )

• impaired under insulin-stimulated conditions

increased adipocyte glucose uptake ( J:194026 )

• increased under basal conditions

decreased skeletal muscle cell glucose uptake ( J:194026 )

• impaired 2-fold in the soleus muscle under basal conditions and blunted under insulin-stimulated conditions

• however, glucose uptake in the extensor digitorum longus is normal