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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adam17tm1.1Rain
targeted mutation 1.1, Elaine W Raines
MGI:5478748
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Adam17tm1.1Rain/Adam17tm1.2Rain
Tg(Tek-cre)12Flv/0
B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv MGI:5478754


Genotype
MGI:5478754
cn1
Allelic
Composition
Adam17tm1.1Rain/Adam17tm1.2Rain
Tg(Tek-cre)12Flv/0
Genetic
Background
B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Rain mutation (0 available); any Adam17 mutation (64 available)
Adam17tm1.2Rain mutation (0 available); any Adam17 mutation (64 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• under represented by 75% at weaning but found at the expected frequency at E18.5

cardiovascular system
• cardiomegaly occurs postnatally as heart to body mass ratio is similar to controls at E18.5
• enlarged at E18.5
• valve cusps appear hyperplastic with a 43% increase in the median number of cells and 57% increase in thickness
• increase in thickness is persistent in adults
• however, unlike in global null mice atrioventricular valve leaflets are not overtly abnormal
• the glycosaminoglycan/proteoglycan-rich spongiosa layer of the extracellular matrix is enlarged with increased space between the granules
• 9 of 13 mutants have at least one cusp with aberrant localization and/or excessive levels of collagen
• in surviving adults
• increase in left ventricular end diastolic dimension in females at 24 to 28 weeks of age
• increase in heart size is primarily due to expansion of the left ventricle
• decrease in ejection fraction ad fractional shortening in males and females at 24 to 28 weeks of age
• increase in aortic valve peak velocity in females at 24 to 28 weeks of age
• at 24 to 28 weeks of age in females

muscle
• decrease in ejection fraction ad fractional shortening in males and females at 24 to 28 weeks of age

growth/size/body
• cardiomegaly occurs postnatally as heart to body mass ratio is similar to controls at E18.5





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory