Phenotypes associated with this allele

• Allele Symbol: Stk11^tm1.1Gne
• Allele Name: targeted mutation 1.1, Genentech
• Allele ID: MGI:5484538
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk11^tm1.1Gne/Stk11^tm1.1Gne	involves: C57BL/6N	MGI:5484545
cn2	Kras^tm4Tyj/Kras^+ Stk11^tm1.1Gne/Stk11^tm1.1Gne	involves: 129S4/SvJae * C57BL/6N	MGI:5484547
cx3	Pdx1^tm1Egs/Pdx1^+ Stk11^tm1.1Gne/Stk11^tm1.1Gne	involves: 129S1/Sv * C57BL/6N	MGI:5484546

Genotype
MGI:5484545

hm1

• Allelic Composition: Stk11^tm1.1Gne/Stk11^tm1.1Gne
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:195229 )

• mice die after E14.5

respiratory system

abnormal lung development ( J:195229 )

• lung explants treated with 1NMPP1 exhibit defects in branching and bud septation with increased terminal bud width and smaller overall size compared with control explants

• lung epitheliam explants treated with 1NMPP1 exhibit defective branching compared with control explants

• wild-type mesenchyme fails to restore normal development of 1NMPP1-treated lung epithelium

• however, treatment with A-769662 (an AMPK activator) rescues development of lung explants treated with 1NMPP1

abnormal branching involved in lung morphogenesis ( J:195229 )

• defective in explants treated with 1NMPP1

• however, treatment with A-769662 (an AMPK activator) rescues development of lung explants treated with 1NMPP1

abnormal lung bud morphology ( J:195229 )

• defective bud septation and increased terminal bud width in explants treated with 1NMPP1

• however, treatment with A-769662 (an AMPK activator) rescues development of lung explants treated with 1NMPP1

Genotype
MGI:5484547

cn2

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Stk11^tm1.1Gne/Stk11^tm1.1Gne
• Genetic Background: involves: 129S4/SvJae * C57BL/6N

endocrine/exocrine glands

pancreas cyst ( J:195229 )

• in pancreatic explants treated with 1NMPP1 and infected with a cre-expressing adenovirus without loss of intrinsic cell polarity

growth/size/body

pancreas cyst ( J:195229 )

• in pancreatic explants treated with 1NMPP1 and infected with a cre-expressing adenovirus without loss of intrinsic cell polarity

Genotype
MGI:5484546

cx3

• Allelic Composition: Pdx1^tm1Egs/Pdx1⁺; Stk11^tm1.1Gne/Stk11^tm1.1Gne
• Genetic Background: involves: 129S1/Sv * C57BL/6N

endocrine/exocrine glands

pancreas cyst ( J:195229 )

• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1

• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity

cellular

increased cell proliferation ( J:195229 )

• increased epithelial cell proliferation accompanies pancreatic cyst formation in 1NMPP1-treated pancreatic explants

growth/size/body

pancreas cyst ( J:195229 )

• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1

• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity