Phenotypes associated with this allele

• Allele Symbol: Sppl2a^chompB
• Allele Name: chompB
• Allele ID: MGI:5484577
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sppl2a^chompB/Sppl2a^chompB	involves: C57BL/6	MGI:5484588

Genotype
MGI:5484588

hm1

• Allelic Composition: Sppl2a^chompB/Sppl2a^chompB
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:194595 )

N • mice exhibit normal numbers of T, NK and myeloid cells and response to TNP-Ficoll

decreased activation-induced B cell apoptosis ( J:194595 )

• in response to anti-IgM and, to a lesser extent, LPS

decreased B cell proliferation ( J:194595 )

• no proliferation in response to anti-IgM

• reduced proliferation in response to LPS and anti-CD40

abnormal class switch recombination ( J:194595 )

• reduced switching to IgG1 after immunization

decreased transitional stage T2 B cell number ( J:194595 )

decreased myeloid dendritic cell number ( J:194595 )

decreased plasmacytoid dendritic cell number ( J:194595 )

decreased mature B cell number ( J:194595 )

• in the bone marrow and peripheral lymph nodes

decreased follicular B cell number ( J:194595 )

decreased marginal zone B cell number ( J:194595 )

abnormal humoral immune response ( J:194595 )

• mice exhibit a decrease in peripheral blood B cells and T cell-dependent antibody responses

decreased IgG1 level ( J:194595 )

• in the serum

• decreased DNP-specific IgG1 after immunization

decreased IgG2b level ( J:194595 )

• in the serum prior to immunization

decreased IgG3 level ( J:194595 )

• in the serum prior to immunization

• however, TNP-specific IgG1 levels are normal after immunization

decreased IgM level ( J:194595 )

• slightly in the serum prior to immunization

• however, DNP-specific or TNP-specific IgM levels are normal after immunization

cellular

decreased activation-induced B cell apoptosis ( J:194595 )

• in response to anti-IgM and, to a lesser extent, LPS

decreased B cell proliferation ( J:194595 )

• no proliferation in response to anti-IgM

• reduced proliferation in response to LPS and anti-CD40

hematopoietic system

decreased activation-induced B cell apoptosis ( J:194595 )

• in response to anti-IgM and, to a lesser extent, LPS

decreased B cell proliferation ( J:194595 )

• no proliferation in response to anti-IgM

• reduced proliferation in response to LPS and anti-CD40

abnormal class switch recombination ( J:194595 )

• reduced switching to IgG1 after immunization

decreased transitional stage T2 B cell number ( J:194595 )

decreased myeloid dendritic cell number ( J:194595 )

decreased plasmacytoid dendritic cell number ( J:194595 )

decreased mature B cell number ( J:194595 )

• in the bone marrow and peripheral lymph nodes

decreased follicular B cell number ( J:194595 )

decreased marginal zone B cell number ( J:194595 )

decreased IgG1 level ( J:194595 )

• in the serum

• decreased DNP-specific IgG1 after immunization

decreased IgG2b level ( J:194595 )

• in the serum prior to immunization

decreased IgG3 level ( J:194595 )

• in the serum prior to immunization

• however, TNP-specific IgG1 levels are normal after immunization

decreased IgM level ( J:194595 )

• slightly in the serum prior to immunization

• however, DNP-specific or TNP-specific IgM levels are normal after immunization