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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mtorchino
chino
MGI:5484589
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mtorchino/Mtorchino involves: C57BL/6JAnu MGI:5565186
cx2
 		Mtorchino/Mtorchino
Rasgrp1m1Anu/Rasgrp1m1Anu 		involves: C57BL/6JAnu * C57BL/6JSfdAnu * CBA/J MGI:5565189


Genotype
MGI:5565186
hm1
Allelic
Composition		 Mtorchino/Mtorchino
Genetic
Background		 involves: C57BL/6JAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtorchino mutation (1 available); any Mtor mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• normal numbers of double positive, CD4 single positive and CD8 single positive thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:207898 )
• decreased numbers of CD4+ T cells in the spleen
• however, the proportion of CD4+ T cells is normal

growth/size/body
decreased body size ( J:207898 )
• slightly

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:207898 )
• decreased numbers of CD4+ T cells in the spleen
• however, the proportion of CD4+ T cells is normal




Genotype
MGI:5565189
cx2
Allelic
Composition		 Mtorchino/Mtorchino
Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 involves: C57BL/6JAnu * C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtorchino mutation (1 available); any Mtor mutation (115 available)
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes

hematopoietic system
hematopoietic system phenotype ( J:207898 )
N
• hematopoietic cells transferred into bone marrow chimeras exhibit normal frequency of animals with antinuclear autoantibodies compared with chimeras receiving Rasgrp1m1Anu cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory