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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdkal1Gt(6062)Tgen
gene trap 6062, TransGenic
MGI:5484736
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen involves: C57BL/6 * C57BL/6J * CBA/JNCrj MGI:5484772


Genotype
MGI:5484772
hm1
Allelic
Composition
Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA/JNCrj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkal1Gt(6062)Tgen mutation (0 available); any Cdkal1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal lipid accumulation in Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen mice on a high fat diet

homeostasis/metabolism
• tendency after 20 weeks on a high fat diet
• at early stages, mice fed a high fat diet exhibit less prominent insulin insensitivity and glucose intolerance compared with wild-type mice
• at late stages, mice fed a high fat diet exhibit more prominent insulin insensitivity and glucose intolerance compared with wild-type mice
• however, mice fed standard chow exhibit normal glucose tolerance
• in mice fed a high fat diet for 8 or 16 weeks
• however, circulating insulin levels are normal after 20 weeks on a high fat diet
• in mice fed a high fat diet for 4 or 8 weeks
• however, circulating glucose levels are normal after 16 or 20 weeks on a high fat diet
• in mice fed a high fat diet for 8 or 16 weeks
• however, circulating insulin levels are normal after 20 weeks on a high fat diet
• in mice fed a high fat diet for 8 or 16 weeks
• in mice fed a high fat diet for 20 weeks
• in mice fed a high fat diet for 8 or 16 weeks
• in mice fed a high fat diet for 20 weeks

muscle
• in mice fed a high fat diet for 8 or 16 weeks
• in mice fed a high fat diet for 20 weeks

adipose tissue
• a high fat diet for 8 weeks
• however, fat pad weight is normal at 16 and weeks
• a high fat diet for 8 weeks
• however, fat pad weight is normal at 16 and weeks

growth/size/body
• at 8, 10 at 11 weeks
• tendency on a high fat diet

behavior/neurological
• tendency in mice fed a high fat diet

endocrine/exocrine glands
• in mice fed a high fat diet for 8 or 16 weeks
• however, circulating insulin levels are normal after 20 weeks on a high fat diet

integument
• a high fat diet for 8 weeks
• however, fat pad weight is normal at 16 and weeks

liver/biliary system
• in mice fed a high fat diet for 8 or 16 weeks
• in mice fed a high fat diet for 20 weeks





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory