Analysis Tools
homeostasis/metabolism
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• mice exhibit normal glucose homeostasis under fed, fasted and re-fed conditions
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• in unchallenged mice
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• in unchallenged and fasted mice
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• in unchallenged mice
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• in fasted mice
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• in fasted mice
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• in fasted mice
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• in fasted mice
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liver/biliary system
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• following a 24 h fast, hepatocytes surrounding the portal veins are more eosinophilic with vacuolization than in perivenous hepatocytes unlike in control mice
• re-fed mice exhibit rapid and variable development of giant vacuoles (dilated rough endoplasmic reticulum) in periportal hepatocytes unlike in control mice
• orally administration of casein to fasted mice exhibit vacuolization of periportal hepatocytes unlike in control mice
• administration of amino acids to fasted mice exhibit varying degrees of hepatocyte vacuolization depending on the amino acid (glutamine, glutamate, glycine>alanine>arginine>lysine) unlike in control mice
• fasted mice treated with ammonium acetate or pyruvate exhibit some degree of vacuolization unlike control mice
• however, oral administration of glucose, urea or triglyceride to fasted mice does not induce vacuolization
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cellular
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• dilated in the hepatocytes of mice that were fasted and re-fed
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